Edrophonium priming alters the course of neuromuscular recovery from a pipecuronium neuromuscular blockade

Abstract

This study was designed to investigate the effect of divided administration of edrophonium on the course of neuromuscular recovery from a pipecuronium neuromuscular blockade. During thiopentone-nitrous oxide-halothane anaesthesia 48 patients were given pipecuronium 70 I.~g" kg-t. Patients were randomly assigned to one of four groups (n = 12 in each) to receive either edrophonium I mg . kg -t (Groups i and Ii) or edrophon. ium O. 75 mg. kg-t (Groups III and IV). in Groups