Educating future nursing scientists: Recommendations for integrating omics content in PhD programs

Conley, Yvette P.; Heitkemper, Margaret; McCarthy, Donna O.; Anderson, Cindy M.; Corwin, Elizabeth J.; Daack-Hirsch, Sandra; Dorsey, Susan G.; Gregory, Katherine E.; Groer, Maureen; Henly, Susan J.; Landers, Timothy; Lyon, Debra E.; Taylor, Jacquelyn Y.; Voss, Joachim

doi:10.1016/j.outlook.2015.06.006

Cited by 31 publications

(23 citation statements)

References 26 publications

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“…The incorporation of genetics/genomics research in Ph.D. programme is advisable as of Ph.D. programmes is advisable as 8% of these relate to genetics/genomics (Wyman & Henly 2015). Such an approach is in line with the vision of the Idea Festival Advisory Committee of linking Ph.D. education with a better preparation for future nursing scientists (Henly et al 2015) and integrating omics into Ph.D. programmes (Conley et al 2015). The Genomics Knowledge Matrix serves as a guide for doctoral education in genetics/genomics and can be viewed on the ONSEN website (Regan et al 2019).…”

Section: Recommendations For Incorporation Of Genomics Educationmentioning

confidence: 99%

Genomics education in nursing in Hong Kong, Taiwan and Mainland China

Waye

Calzone

Chan

2019

International Nursing Review

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Aim: To identify issues and challenges of genomics education in Hong Kong, Taiwan and Mainland China. Background: The use of genetics/genomics in health care, such as genetic testing, pharmacogenomics and tumour profiling in the context of cancer, is increasing. The rapid application of genetics/genomics in clinical practice requires healthcare providers to be competent to practise genetics-related patient care. Sources of evidence: We reviewed current practices in genomics education in nursing in Hong Kong, Taiwan and Mainland China, including the opportunities for nurses to advance their knowledge and recommendations to incorporate genomics education in the nursing curriculum in these regions. Findings: While many citizens and health professionals recognize the importance of new and exciting research areas of genomics/genetics, there are still many gaps in the translation of genetic/genomic medicine into clinical practice. There is also a similar lack of genetics professionals in China. Conclusion: Hong Kong, Taiwan and Mainland China face challenges in promoting genetic education in nursing. A strategic approach in a coordinated effort ineffectively translating genomic knowledge into healthcare practice should be established in these three regions. Implications for nursing and policy: Nursing educators in Hong Kong, Taiwan and Mainland China should link with the international nursing community (e.g. Global Genomics Nursing Alliance) and form closer networks to improve education in the area of genetics and genomics. From a policy level, genomics education is suggested to be incorporated in nursing curriculum to enhance nurses’ competency in incorporating genetics/genomics service into patient care.

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Section: Recommendations For Incorporation Of Genomics Educationmentioning

confidence: 99%

Genomics education in nursing in Hong Kong, Taiwan and Mainland China

Waye

Calzone

Chan

2019

International Nursing Review

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“…Additionally, since breast milk may be influenced by maternal genotypes, findings from this study may impact how donor milk is batched at milk banks for pasteurization. Perhaps more global to the impact of this study's findings on nursing is the importance of preparedness in nurse-scientists in genomics (Conley et al, 2015), particularly as to how genetics/genomics informs screening and prognoses (Calzone & Jenkins, 2011). …”

Section: Discussionmentioning

confidence: 99%

Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants

Baumgartel

Groër

Cohen

et al. 2016

Biological Research For Nursing

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Background Maternal interleukin (IL) single nucleotide polymorphisms (SNPs) are associated with obstetrical outcomes. Conversely, infant SNPs are associated with subsequent neonatal intensive care unit (NICU) outcomes. Little is known about relationships between maternal SNPs and neonatal outcomes. Purpose To examine the relationships between maternal IL genotypes and neonatal outcomes. Methods An ancillary study was conducted among mothers (N = 63) who delivered very low-birth-weight infants (N = 74). Maternal DNA was extracted from breast milk and genotyped. Outcomes included fecal calprotectin, length of stay, scores for neonatal acute physiology with perinatal extension (SNAPPE-II), weight gain, oxygen needs, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, retinopathy of prematurity, blood transfusions, and feeding intolerance. Multivariate analyses examined the relationships between maternal IL SNPs and outcomes, controlling for gestational age and the ratio of maternal milk to total milk. Results Absence of a minor allele in 2 IL6 SNPs was associated with fecal calprotectin (p = .0222, p = .0429), length of stay (p = .0158), SNAPPE-II (p = .0497), weight gain (p = .0272), and days on oxygen (p = .0316). IL6 genotype GG (rs1800795) was associated with length of stay (p = .0034) and calprotectin (p = .0213). Minor-allele absence in 2 IL10 SNPs was associated with days on oxygen (p = .0320). There were associations between IL10 genotype TT (rs1800871) and calprotectin (p = .0270) and between IL10 genotypes AA (rs1800872 and rs1800896) and calprotectin (p = .0158, p = .0045). Conclusion Maternal IL SNPs are associated with NICU outcomes. A potential clinical application includes an antenatal risk profile to identify neonatal needs.

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“…However, the reliability, accuracy, and clinical manifestations associated with genetic variants identified by whole genome sequencing remain largely unknown because research studies focused on affected individuals do not evaluate population-based data or individuals with the variant who are unaffected (Williams, Cashion, & Veenstra, 2015). As public policy statements evolve, the practical implications of new developments in DNA sequencing for nurses will include the need to keep curricula in nursing education programs up-to-date (Calzone et al, 2013; Conley et al, 2015) as new sequencing and therapeutic modalities based on this screening are brought into practice (Wright, Housman & Taylor, 2016). For nurses already in practice, it is critical that in-service education programs be made available so that nurses will have useful resources to integrate the new information into their day-to-day nursing activities effectively.…”

Section: The Current Policy Landscapementioning

confidence: 99%

Genome Sequencing Technologies and Nursing

et al. 2017

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Background Advances in DNA sequencing technology have resulted in an abundance of personalized data with challenging clinical utility and meaning for clinicians. This wealth of data has potential to dramatically impact the quality of healthcare. Nurses are at the focal point in educating patients regarding relevant healthcare needs; therefore, an understanding of sequencing technology and utilizing these data are critical. Aim The objective of this paper is to explicate the role of nurses and nurse scientists as integral members of healthcare teams in improving understanding of DNA sequencing data and translational genomics for patients. Approach A history of the nurse role in newborn screening is used as an exemplar. Discussion This paper serves as an exemplar on how genome sequencing has been utilized in nursing science and incorporates linkages of other omics approaches used by nurses that are included in this special issue. This special issue showcased nurse scientists conducting multi-omic research from various methods, including targeted candidate genes, pharmacogenomics, proteomics, epigenomics and the microbiome. From this vantage point, we provide an overview of the roles of nurse scientists in genome sequencing research and provide recommendations for the best utilization of nurses and nurse scientists related to genome sequencing.

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Educating future nursing scientists: Recommendations for integrating omics content in PhD programs

Cited by 31 publications

References 26 publications

Genomics education in nursing in Hong Kong, Taiwan and Mainland China

Genomics education in nursing in Hong Kong, Taiwan and Mainland China

Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants

Genome Sequencing Technologies and Nursing

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