Education by a Nurse Increases Response of Patients With Chronic Hepatitis C to Therapy With Peginterferon-α2a and Ribavirin

Larrey, Dominique; Salse, A.; Ribard, D; Boutet, Olivier; Hyrailles–Blanc, Valérie; Niang, B.; Pageaux, Georges Philippe; Vaucher, E; Arpurt, Jean Pierre; Boulay, Guy; Karlova, Natalia; Daurès, Jean Pierre

doi:10.1016/j.cgh.2011.05.022

Cited by 34 publications

(30 citation statements)

References 14 publications

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“…The current study revealed that, there is statistically significant improvement of patients' self-efficacy post program than preprogram at .043, where the percentage of higher selfefficacy increase from 0% preprogram to 70% post program; this could be due to reduction of the emotional distress (anxiety and depression), reduction of physical symptoms and due to improvement on the liver enzymes or due to increasing their awareness' about the temporary side effect of the drugs and patients prognosis. The present result was agreement with [40] who showed that A recent Cochrane review provided evidence of the effectiveness of patient support and education interventions, reporting that;" interventions targeting practical medication management skills, administered to individuals (vs groups), and delivered over at least 12 weeks were associated with improved adherence outcomes". Moreover, this result supported by [41], they performed a prospective study to determine the effects of systematic consultation by a nurse on patient adherence and the efficacy of therapy, they concluded that; "therapeutic education by a specialized nurse increases the response of patients with hepatitis C to therapy, particularly in difficult-to-treat patients".…”

Section: Discussionsupporting

confidence: 80%

The Effectiveness of Nursing Intervention Program on Emotional Distress, Self-Efficacy, and Liver Enzymes Among Hepatitis C Virus Patients Undergoing Antiviral Treatment Therapy (Sovaldi Medication)

Malky¹,

Gahsh²,

Atia³

2016

AJNS

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Almost all patients receiving hepatitis C antiviral therapy will experience some treatment-related adverse effects.Emotional distress and fatigue can lead to early treatment discontinuation. Close monitoring is crucial throughout treatment. The nurses can promote adherence by counseling patients on the recognition and management of treatment-related adverse effects. The purpose of the study was to evaluate the effectiveness of nursing intervention program on emotional distress, selfefficacy and liver enzymes among hepatitis C Virus patients undergoing antiviral treatment therapy (Sovaldi medication). Quasi experimental design (one group pre/posttest) was used to achieve the aim of the study. The study was conducted in the Liver Institute at Shebin El kom District, Menoufia Governorate. A purposeful sample of 50 patients with hepatitis C virus patients undergoing antiviral treatment therapy (Sovaldi medication) from the above setting were recruited. Three instrument were used for data collection (1): Structured interview questionnaire to assess demographic and clinical data (2): Hospital anxiety and depression scale to measure emotional distress. (3): Self-efficacy scale to measure patients' self-efficacy. The result revealed that there were statistical significant improvements of patient's knowledge, patients' emotional distress, liver enzymes and self-efficacy post program than preprogram. Conclusion: Nursing intervention program is the key element for management of patients' emotional distress, self-efficacy and reduction of liver enzymes. Recommendation: psych educational program should be given for all patients with hepatitis C virus undergoing antiviral treatment therapy to improve their knowledge about the drug and promote adherence by counseling patients on the recognition and management of treatment related adverse effect. Encourage them to discuss their problem with health care team and participate in self-help program to decrease emotional distress and increase self-efficacy.

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Section: Discussionsupporting

confidence: 80%

The Effectiveness of Nursing Intervention Program on Emotional Distress, Self-Efficacy, and Liver Enzymes Among Hepatitis C Virus Patients Undergoing Antiviral Treatment Therapy (Sovaldi Medication)

Malky¹,

Gahsh²,

Atia³

2016

AJNS

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“…Research indicates that nurses play a crucial role in providing education, support and management of patients infected with hepatitis C [58-61]. The involvement of nurses enhances access to treatment, treatment adherence and response to treatment [58,61,62].…”

Section: Programmes Developed To Improve Hcv Treatment In Prisonmentioning

confidence: 99%

“…The involvement of nurses enhances access to treatment, treatment adherence and response to treatment [58,61,62]. A recent study by Lloyd et al (Lloyd et al 2013) evaluated the safety and effectiveness of a nurse model of care for inmates.…”

Section: Programmes Developed To Improve Hcv Treatment In Prisonmentioning

confidence: 99%

Hepatitis C in European prisons: a call for an evidence-informed response

2014

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Globally, over 10 million people are held in prisons and other places of detention at any given time. People who inject drugs (PWID) comprise 10-48% of male and 30-60% of female prisoners. The spread of hepatitis C in prisons is clearly driven by injection drug use, with many infected prisoners unaware of their infection status. Risk behaviour for acquisition of hepatitis C via common use of injecting equipment is widespread in many prison settings.In custodial settings, effective and efficient prevention models applied in the community are very rarely implemented. Only approximately 60 out of more than 10,000 prisons worldwide provide needle exchange. Thus, HCV prevention is almost exclusively limited to verbal advice, leaflets and other measures directed to cognitive behavioural change. Although the outcome of HCV antiviral treatment is comparable to non-substance users and substance users out of prison, the uptake for antiviral treatment is extremely low.Based on a literature review to assess the spread of hepatitis C among prisoners and to learn more about the impact for the prison system, recommendations regarding hepatitis C prevention, screening and treatment in prisons have been formulated in this article.

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“…For example, for patients living with HIV and receiving antiretroviral treatment, a stable partnership is associated with a slower progression to AIDS or death [57]; and among patients living with HCV, those who are married are more likely to complete dual therapy [43]. In addition to companionship, close social contact is known to have multifaceted benefits, including emotional, instrumental, informational support [34, 58, 59]. …”

Section: Discussionmentioning

confidence: 99%

“Fighting an uphill battle”: experience with the HCV triple therapy: a qualitative thematic analysis

et al. 2014

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BackgroundHepatitis C virus (HCV) infections are a severe burden on public health worldwide, causing mortality rates triple that of the general population. Since 2011, for both therapy-naive and therapy-experienced genotype 1 patients, the first generation of direct acting antivirals (DAAs), i.e., the protease-inhibitors (PI) telaprevir and boceprevir have been added to existing dual therapies. The therapeutic effect of the resulting triple therapy is striking; however, treatment regimens are complex and commonly cause side effects. Little is known of how patients implement therapy in their daily lives, or of how they deal with these effects.This study aims to describe HCV patients' experiences with protease-inhibitor-based triple therapy and their support needs.MethodsA qualitative design was used. Patients from three outpatient clinics, with ongoing, completed or discontinued PI treatment experience were recruited using a maximum variation sampling approach. Open-ended interviews were conducted and analyzed using thematic analysis according to Braun & Clarke (Qual Res Psychol 3:77-101, 2006).ResultsThirteen patients participated in the interviews. All described themselves as highly motivated to undergo treatment, since they saw the new therapy as a “real chance” for a cure. However, all later described the therapy period as a struggle. The constitutive theme–“Fighting an uphill battle”– describes the common existential experience of and negative consequences of coping with side effects. The processes that fostered this common experience followed three sub-themes: “encountering surprises”, “dealing with disruption” and “reaching the limits of systems”.ConclusionHCV patients undergoing outpatient protease-inhibitor-based triple therapy need systematic support in symptom management. This will require specially trained professionals to advise and support them and their families, and to provide rapid responses to their needs throughout this complex course of therapy. As the generation of DAAs for all genotypes, are expected to have less severe side effects, and many HCV patients require treatment, this knowledge can improve treatment support tremendously, especially for patients who are quite difficult to treat. Furthermore, these findings are helpful to illustrate development in HCV treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2334-14-507) contains supplementary material, which is available to authorized users.

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Education by a Nurse Increases Response of Patients With Chronic Hepatitis C to Therapy With Peginterferon-α2a and Ribavirin

Cited by 34 publications

References 14 publications

The Effectiveness of Nursing Intervention Program on Emotional Distress, Self-Efficacy, and Liver Enzymes Among Hepatitis C Virus Patients Undergoing Antiviral Treatment Therapy (Sovaldi Medication)

The Effectiveness of Nursing Intervention Program on Emotional Distress, Self-Efficacy, and Liver Enzymes Among Hepatitis C Virus Patients Undergoing Antiviral Treatment Therapy (Sovaldi Medication)

Hepatitis C in European prisons: a call for an evidence-informed response

“Fighting an uphill battle”: experience with the HCV triple therapy: a qualitative thematic analysis

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