Recognizing that the quality of secondary education encompasses more than academic achievement alone, it's crucial to acknowledge the significant role played by the overall organizational health of schools. This includes various elements such as effective leadership, access to professional development opportunities, and the promotion of cultural inclusivity. However, existing literature on school organizational health lacks cohesion in terms of its antecedents and lacks empirically tested research. Therefore, this study addresses two key gaps in the literature: firstly, whether Professional Development, Transformational Leadership, and Cultural Intelligence impact School Organizational Health; and secondly, how this impact compares between Indian and Ethiopian schools. To investigate this, a factorial design of 2x2x2x2 was analyzed using stepwise regression, based on data collected from 600 respondents. The results confirmed that Professional Development, Transformational Leadership, and Cultural Intelligence significantly influence school organizational health in both Indian and Ethiopian secondary schools. Furthermore, the predictive power of these factors appeared to be notably stronger within the Ethiopian context, as evidenced by the higher R 2 value and the greater explained variance.