Educational Case: Extranodal NK/T-Cell Lymphoma, Nasal Type

Jia, Yongping; Byers, Joshua T.; Mason, Holli; Qing, Xin

doi:10.1177/2374289519893083

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…On Immunohistochemistry, cytoplasmic CD3ε+, CD56+ and germline T-cell receptor (TCR) positivity and on In-situ hybridization, EBV encoded RNA can be demonstrated. 7,8 Wegener's Granulomatosis (WG) is a multi-system disease characterized by necrotizing granulomatous inflammation which is immune mediated, and can present as MLDs. Histologically, necrotizing vasculitis along with noncaseating multinucleated giant cell granulomas in an inflammatory background helps in the diagnosis of WG.…”

Section: Discussionmentioning

confidence: 99%

Midline destructive lesions: A diagnostic challenge

Srinivasamurthy

2023

IJPO

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Midline destructive lesions (MDLs) are a diagnostic challenge due to an extensive differential diagnosis and vague presenting signs and symptoms. It may be due to neoplastic, autoimmune, traumatic, infectious, or unknown. The lethal lesions are characterized by ulcerative destruction of midline structures of the face like the nose, paranasal sinus and palate. A spectrum of diseases with myriad clinicopathological features can present as midline destructive lesions. Immunohistochemistry has played a major role in discerning the wide range of diseases into specific categories over the years.

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Section: Discussionmentioning

confidence: 99%

Midline destructive lesions: A diagnostic challenge

Srinivasamurthy

2023

IJPO

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“…Immunohistochemistry stains show the absence of surface CD4, CD5, and CD8 on the tumor cells while staining positive for cytotoxic molecules (granzyme B, perforin, and TIA-1) and CD2, CD3e, and CD56 [ 13 ]. Additionally, in situ hybridization for EBV-encoded early RNA (EBER) will be positive [ 14 ]. Routine blood counts and serum biochemistry, as well as a trephine biopsy, are required as part of the workup to diagnose eNKTL.…”

Section: Discussionmentioning

confidence: 99%

Extranodal Natural Killer/T-cell Lymphoma With an Unusual Presentation: A Case Report and Literature Review

Alyahya¹,

Alhedaithy²,

Abualhamayel³

et al. 2022

Cureus

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The Epstein-Barr virus is closely linked to a lymphoproliferative disease known as natural killer/T-cell lymphoma (NKTL). Early identification of NKTL might be challenging because it can resemble other nasopharyngeal pathologies. Contrary to the presented case, T-cell lymphoma often develops in the nasal canal and spreads to the oral cavity. Here, we present the case of a 45-year-old man with an unusual presentation of NKTL presenting initially as acute follicular tonsillitis.

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“…The likelihood of survival is contingent upon the specific type of disease and the stage at which it is diagnosed 116 . This condition is characterized by the predominant occurrence of vascular injury and necrosis, along with a notable association with EBV 117 . The primary manifestation of this condition mostly manifests as nasal involvement.…”

Section: T/nk Lymphomasmentioning

confidence: 99%

Epstein-Barr virus: Ubiquitous virus with multifarious implication in oral diseases material and methods results

Koumpouli,

Karavida,

Zisis

et al. 2024

Balkan J Dent Med

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Epstein Barr virus (EBV) is the first virus identified to possess the capacity to induce various benign and malignant conditions. These conditions encompass asymptomatic persistent infection, self-limited disease in individuals with a competent immune system, and the propensity to initiate different tumors formation (oncogenesis) even head and neck cancer. Notably, EBV may interact with other viruses including human papillomavirus (HPV) especially in immunosuppressed patients, leading to a synergistic effect. The objective of this study is to conduct a comprehensive literature review on the Epstein-Barr virus (EBV), focusing on its life cycle within the human host, the pathogenic mechanisms associated with the virus, the specific types of head and neck cancers in which EBV is implicated, and the interactions between EBV and other viruses in immunosuppressed individuals. Epstein-Barr virus (EBV) remains in most cases, asymptomatic or leads to the development of infectious mononucleosis. Moreover, it plays a significant role in the development of cancer, particularly in individuals under immunosuppression. The viral infection typically persists within the host organism in either a dormant or lytic state. The research also addresses the topic of chronic activated Epstein-Barr virus (EBV) syndrome, exploring its interactions with other pathogenic viruses. In addition to presenting oral manifestations in the form of infectious mononucleosis, the Epstein-Barr virus (EBV) is linked to the occurrence of nasopharyngeal carcinoma, Hodgkin and Non-Hodgkin lymphomas in the head and neck region. Furthermore, EBV is associated with the development of hairy leukoplakia in individuals with weakened immune systems due to HIV. Overall, EBV may play a role in the etiology and pathogenesis of oral squamous epithelium carcinoma either independently or in conjunction with human papillomavirus (HPV). The manifold role of EBV necessitates the accurate diagnosis of new cases and the vigilant monitoring of the patients in order to avoid or at least delay the long term repercussions on the patients' health and quality of life.

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Educational Case: Extranodal NK/T-Cell Lymphoma, Nasal Type

Cited by 4 publications

References 16 publications

Midline destructive lesions: A diagnostic challenge

Midline destructive lesions: A diagnostic challenge

Extranodal Natural Killer/T-cell Lymphoma With an Unusual Presentation: A Case Report and Literature Review

Epstein-Barr virus: Ubiquitous virus with multifarious implication in oral diseases material and methods results

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