This study aims to analyze the challenges and opportunities in leadership transformation at Mulawarman University, East Kalimantan. The research method used was a qualitative approach with interviews and observations as data collection techniques. The results showed that rapid student growth, improving education quality, changes in education technology, and tensions between central policies and local needs were the main challenges in leadership transformation. On the other hand, opportunities arise in the form of improving the university's reputation and partnerships with local government and industry. The interviews also revealed the important role of intellectual leaders in creating positive change in the region. This research provides an in-depth understanding of the complexities of leadership transformation in the context of higher education in East Kalimantan. Recommendations for future research are to involve more universities, apply more extensive qualitative methods, and involve external stakeholders. This study concludes that universities have the potential to play an active role in regional development and create a positive impact through intellectual leadership focused on sustainable change.