EEF1A1 (eukaryotic translation elongation factor 1 alpha 1)

Abstract

Review on EEF1A1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.

Evidence for a synergistic effect of post‐translational modifications and genomic composition of eEF‐1α on the adaptation of Phytophthora infestans

“…Only two amino acid isoforms were identified in the 10 nucleotide haplotypes generated from 165 isolates. The observed low genetic variation is consistent with the theoretical expectation for housekeeping genes (Zhang & Li, 2004) where reduced evolution can ensure functional conservation critical to the survival, proliferation and therefore fitness of species (Scaggiante & Bosutti, 2015) including pathogens. We hypothesize that the lower genetic variation is caused by purifying selection (Viscidi & Demma, 2003) coupled with a lack of recombination rather than a reduced mutation rate in the gene and we have two lines of evidence to support this argument.…”

Fitness difference between two synonymous mutations of Phytophthora infestans ATP6 gene

“…Furthermore, quantitative analysis of functional traits reveals significant variations in fitness among the haplotypes, consistent with a current report in yeast using ∼ 8,500 synonymous mutants generated from > 20 endogenous genes [ 69 ]. The conserved evolution, together with significant difference in the fitness components among the haplotypes suggests the ATP6 is under strong natural selection to purge its genetic variation, consistent with the theoretical expectation for genome essential to maintain basic cellular functions [ 70 ]. The conserved evolution in housekeeping genes has been reported in the concerned pathogen [ 71 ] as well as other species across kingdoms [ 72 – 74 ].…”