Eeg and Auditory Evoked Potential P300 Compared With Psychometric Tests in Assessing Vigilance After Benzodiazepine Sedation and Antagonism

Engelhardt, W.; Friess, K.; Hartung, E.; Sold, M.; Dierks, Thomas

doi:10.1093/bja/69.1.75

Cited by 35 publications

(21 citation statements)

References 22 publications

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“…As P300 amplitude has been found to be smaller in more difficult tasks (Fitzgerald and Picton 1983), the higher levels of sedation and subjective disturbances and the decreased P300 amplitude may be interpreted as an index of increased task complexity perceived by the subjects. The result of reduced P300 amplitude and increased P300 latency is more or less in line with results obtained with other benzodiazepines (Domino et al 1989;Engelhardt et al 1992;Martin et al 1992;Meador et al 1991;Milligan et al 1989;Ray et al 1992;Rockstroh et al 1991;Shinotoh et al 1989). As already discussed with respect to our results on N1 and P2, an unresolved issue is the extent to which the impairing effect on cognition is separable from sedative effects.…”

Section: Discussionsupporting

confidence: 92%

Acute effects of the anxiolytics suriclone and alprazolam on cognitive information processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects

Semlitsch

Anderer

Saletu

1995

Eur J Clin Pharmacol

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In a double-blind, placebo-controlled, cross-over study, acute effects of suriclone--a cyclopyrrolone derivative--were investigated by means of topographic mapping of event-related potentials (ERPs). Fifteen normal volunteers, aged 22-35 years, received randomized, oral single doses of placebo, 0.1 mg, 0.2 mg and 0.4 mg suriclone and 1 mg alprazolam as a reference compound. ERPs were investigated in an auditory oddball paradigm before and 3 h after intake of each drug. In addition to 17 EEG leads, vertical and horizontal electro-oculograms (EOGs) were recorded. After EOG minimization and artifact identification, the peak latencies of the spatial average were determined by an automatic procedure. Compared to placebo, no significant effects of the low and middle doses of suriclone on N1 amplitude were observed; the highest dosage reduced N1 amplitude, as did 1 mg alprazolam to an even greater extent. While no consistent effects on P2 amplitude were observed after suriclone, alprazolam reduced P2 amplitude. P300 amplitude was reduced only after the highest dosage of suriclone, but much more so after alprazolam. P300 latency was not affected significantly by suriclone, but a marked prolongation of P300 latency was observed after 1 mg alprazolam. Concerning N1 and P2 effects, alprazolam, but not suriclone, may have an inhibitory influence on stimulus-induced cortical arousal. Concerning P300 effects, the used doses of suriclone were superior to 1 mg alprazolam, which seemed to have reduced cognitive information processing capacity and prolonged stimulus evaluation time. Self-rated well-being (adjective checklist) showed subtle beneficial effects after 0.1 mg and 0.2 mg, but marked sedative effects after both 0.4 mg suriclone and 1 mg alprazolam.

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Section: Discussionsupporting

confidence: 92%

Acute effects of the anxiolytics suriclone and alprazolam on cognitive information processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects

Semlitsch

Anderer

Saletu

1995

Eur J Clin Pharmacol

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“…For example, the decline of performance with the P300-BCI in participant B corresponded to the increasing dosage of morphine against phantom limb pain. Similarly benzodiazepines to reduce anxiety affect alertness and the P300 evoked potential (Engelhardt et al, 1992; Hayashi, 2000). …”

Section: Discussionmentioning

confidence: 99%

The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis - a longitudinal study

2010

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The current study investigated the effects of psychological well-being measured as quality of life (QoL), depression, current mood and motivation on brain–computer interface (BCI) performance in amyotrophic lateral sclerosis (ALS). Six participants with most advanced ALS were trained either for a block of 20 sessions with a BCI based on sensorimotor rhythms (SMR) or a block of 10 sessions with a BCI based on event-related potentials, or both. Questionnaires assessed QoL and severity of depressive symptoms before each training block and mood and motivation before each training session. The SMR-BCI required more training than the P300-BCI. The information transfer rate was higher with the P300-BCI (3.25 bits/min) than with the SMR-BCI (1.16 bits/min). Mood and motivation were related to the number of BCI sessions. Motivational factors, specifically challenge and mastery confidence, were positively related to BCI performance (controlled for the number of sessions) in tow participants, while incompetence fear was negatively related with performance in one participant. BCI performance was not related to motivational factors in three other participants nor to mood in any of the six participants. We conclude that motivational factors may be related to BCI performance in individual subjects and suggest that motivational factors and well-being should be assessed in standard BCI protocols. We also recommend using P300-based BCI as first choice in severely paralyzed patients who present with a P300 evoked potential.

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“…Several studies in rodents show that GABA A agonists impair learning and memory while GABA A antagonists enhance memory (29,62). It is also known that in humans benzodiazepines may impair cognition (46,71,86). On the other hand, ó receptor agonists enhance memory performance in young rodents and in rodent models of cognitive impairment (89,90,(92)(93)(94)136).…”

Section: Neurochemical Activities Of Dhea and Related Neurosteroidsmentioning

confidence: 99%

Dehydroepiandrosterone (DHEA) and the Aging Brain: Flipping a Coin in the “Fountain of Youth”

2003

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The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic age-related decline that supports significant involvement of DHEA(S) in the aging process. Particularly relevant to the aging process is the functional decline that involves memory and cognitive abilities. DHEA is derived mainly from synthesis in the adrenal glands and gonads. It can also be detected in the brain where it is derived from a synthesis that is independent from peripheral steroid sources. For this reason DHEA and other steroid molecules have been named "neurosteroids." Pharmacological studies on animals provided evidence that neurosteroids could be involved in learning and memory processes because they can display memory-enhancing properties in aged rodents. However, human studies have reported contradictory results that so far do not directly support the use of DHEA in aging-related conditions. As such, it is important to remember that plasma levels of DHEA(S) may not reflect levels in the central nervous system (CNS), due to intrinsic ability of the brain to produce neurosteroids. Thus, the importance of neurosteroids in the memory process and in age-related cognitive impairment should not be dismissed. Furthermore, the fact that the compound is sold in most countries as a health food supplement is hampering the rigorous scientific evaluation of its potential. We will describe the effect of neurosteroids, in particular DHEA, on neurochemical mechanism involved in memory and learning. We will focus on a novel effect on a signal transduction mechanism involving a classical "cognitive kinase" such as protein kinase C. The final objective is to provide additional tools to understand the physiological role and therapeutic potentials of neurosteroids in normal and/or pathological aging, such as Alzheimer's disease.

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Eeg and Auditory Evoked Potential P300 Compared With Psychometric Tests in Assessing Vigilance After Benzodiazepine Sedation and Antagonism

Cited by 35 publications

References 22 publications

Acute effects of the anxiolytics suriclone and alprazolam on cognitive information processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects

Acute effects of the anxiolytics suriclone and alprazolam on cognitive information processing utilizing topographic mapping of event-related brain potentials (P300) in healthy subjects

The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis - a longitudinal study

Dehydroepiandrosterone (DHEA) and the Aging Brain: Flipping a Coin in the “Fountain of Youth”

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