EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

Semyachkina-Glushkovskaya, Oxana; Karavaev, Anatoly S.; Прохоров, М. Д.; Runnova, Anastasiya E.; Боровкова, Е И; Yu.M., Ishbulatov; Hramkov, Alexey N.; Kulminskiy, D. D.; Semenova, Nadezhda; Sergeev, K.S.; Slepnev, Andrei V.; Yu., Sitnikova E.; Zhuravlev, Maksim O.; Fedosov, Ivan V.; Shirokov, Alexander; Blokhina, Inna; Dubrovski, Alexander; Terskov, Andrey; Khorovodov, Alexander; Ageev, Vasily; Elovenko, Dariya; Evsukova, Arina; Adushkina, Viktoria; Telnova, Valeria; Postnov, Dmitry E.; Penzel, Thomas; Kurths, Jürgen

doi:10.1016/j.csbj.2022.12.019

Cited by 15 publications

(25 citation statements)

References 76 publications

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“…Our data demonstrating the mechanisms underlying BBBO and activation of the brain drainage system are presented in Refs. [ 39 , 41 , 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

“…The study of mechanisms of photo-modulation of the brain drainage system is still in its infancy. In our previous studies, we demonstrated that BBBO is accompanied by activation of removal of unnecessary substances from the brain via the meningeal lymphatic vessels (MLVs) [ 39 , 41 , 84 , 85 ]. We observed a similar activation of the MLVs after sound-induced BBBO [ 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our previous studies, we demonstrated that BBBO is accompanied by activation of removal of unnecessary substances from the brain via the meningeal lymphatic vessels (MLVs) [ 39 , 41 , 84 , 85 ]. We observed a similar activation of the MLVs after sound-induced BBBO [ 84 , 85 ]. The BBBO-mediated activation of the MLVs might be explained by the expression of similar proteins in the lymphatic and blood vessel endothelium, including CLND-5, ZO-1, JAM, VE-cadherin, CD31 [ 86 , 87 ].…”

Section: Discussionmentioning

confidence: 99%

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Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Semyachkina-Glushkovskaya

Bragin

Bragina

et al. 2023

Pharmaceutics

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The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of opening of the BBBB (BBBO) by low-level laser treatment (LLLT, 1268 nm) in the mouse cortex. LLLT-BBBO is accompanied by activation of the brain drainage system contributing effective delivery of liposomes into glioblastoma (GBM). The LLLT induces the generation of singlet oxygen without photosensitizers (PSs) in the blood endothelial cells and astrocytes, which can be a trigger mechanism of BBBO. LLLT-BBBO causes activation of the ABC-transport system with a temporal decrease in the expression of tight junction proteins. The BBB recovery is accompanied by activation of neuronal metabolic activity and stabilization of the BBB permeability. LLLT-BBBO can be used as a new opportunity of interstitial PS-free photodynamic therapy (PDT) for modulation of brain tumor immunity and improvement of immuno-therapy for GBM in infants in whom PDT with PSs, radio- and chemotherapy are strongly limited, as well as in adults with a high allergic reaction to PSs.

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“…Our data demonstrating the mechanisms underlying BBBO and activation of the brain drainage system are presented in Refs. [ 39 , 41 , 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Semyachkina-Glushkovskaya

Bragin

Bragina

et al. 2023

Pharmaceutics

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“…Both imaging studies effectively reflected GS function in the same group of subjects (Gu et al., 2023). Furthermore, a recent study suggested that the EEG could be used as a biomarker for the activity of the lymphatic system in the brain, which has been verified in rats with opened BBB or deep‐sleeping (Semyachkina‐Glushkovskaya et al., 2023). This may provide an alternative to noninvasive GS screening.…”

Section: Assessment Of the Gs And Mlvs In Animal Models And Human Stu...mentioning

confidence: 95%

The cerebral lymphatic drainage system and its implications in epilepsy

Peng,

Xie,

Liu

et al. 2023

J of Neuroscience Research

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The central nervous system has long been thought to lack a clearance system similar to the peripheral lymphatic system. Therefore, the clearance of metabolic waste in the central nervous system has been a subject of great interest in neuroscience. Recently, the cerebral lymphatic drainage system, including the parenchymal clearance system and the meningeal lymphatic network, has attracted considerable attention. It has been extensively studied in various neurological disorders. Solute accumulation and neuroinflammation after epilepsy impair the blood–brain barrier, affecting the exchange and clearance between cerebrospinal fluid and interstitial fluid. Restoring their normal function may improve the prognosis of epilepsy. However, few studies have focused on providing a comprehensive overview of the brain clearance system and its significance in epilepsy. Therefore, this review addressed the structural composition, functions, and methods used to assess the cerebral lymphatic system, as well as the neglected association with epilepsy, and provided a theoretical basis for therapeutic approaches in epilepsy.

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“…These pioneering results are an important informative platform for the development of fundamentally new technologies for studying and controlling the restorative mechanisms of sleep [ 9 , 28 , 82 , 83 ]. Pilot studies on rats show that sleep and opened BBB are equally accompanied by BWRS activation, which has an identical effect on the EEG dynamics and makes it possible to identify EEG markers of increased BBB permeability [ 84 ]. Non-invasive technology for assessing the BBB using only EEG is important for monitoring BBB permeability during surgery in order to control the depth of anesthesia and for the analysis of the progression of a number of brain diseases, such as AD and Parkinson’s disease, brain trauma, diabetic and COVID-19 cerebrovascular injuries, and depression [ 16 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ].…”

Section: Therapeutic Properties Of Activation Of Brain Waste Removal ...mentioning

confidence: 99%

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

Semyachkina-Glushkovskaya

Fedosov

Penzel

et al. 2023

IJMS

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Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases.

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EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

Cited by 15 publications

References 76 publications

Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

The cerebral lymphatic drainage system and its implications in epilepsy

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

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