EEG/ERP-based biomarker/neuroalgorithms in adults with ADHD: Development, reliability, and application in clinical practice

Müller, Andreas; Vetsch, Sarah; Pershin, Ilia; Candrian, Gian; Baschera, Gian-Marco; Kropotov, Juri D.; Kasper, Johannes; Rehim, Hossam Abdel; Eich, Dominique

doi:10.1080/15622975.2019.1605198

Cited by 36 publications

(36 citation statements)

References 32 publications

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“…For a successful establishment of biomarkers in the clinical setting, we need more complex approaches, combining multiple neuronal and behavioral markers to distinguish ADHD and healthy controls. 20 However, as stated previously, 48 a single neurophysiological marker can reflect individual profiles of specific functional impairments, which possibly show only small differences, on the group level because of large inter-individual variance, in both ADHD and healthy controls. Moreover, the ERPs analyzed in this study may represent summations of hidden components, so that the decomposition of those deflections into latent components by blind source separation methods might enhance the effect sizes.…”

Section: Discussionmentioning

confidence: 90%

“…This task was used in a set of previous studies. 10,20,32,33 The test compromises 400 trials, of which each consists of a pair of consecutively presented visual stimuli (animals, plants, and humans). In Go-trials (animal–animal), a picture of an animal is followed by a picture of an animal, and the participant is asked to press a button.…”

Section: Methodsmentioning

confidence: 99%

“…On an individual level, they provide valuable information about neuronal processing and executive functions. 19,20 For example, P3 deflections are related to attentional resources and reorientation, 21 whereas the late CNV reflects task-set representation 22 and anticipatory attention. 23 The NoGo and Go trials’ ERP difference curve was associated with conflict detection (N2d) and inhibition of action (P3d).…”

Section: Introductionmentioning

confidence: 99%

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Behavioral and Neurophysiological Markers of ADHD in Children, Adolescents, and Adults: A Large-Scale Clinical Study

Münger

Candrian²,

Kasper³

et al. 2021

Clin EEG Neurosci

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This study aimed to re-evaluate the possible differences between attention-deficit/hyperactivity disorder (ADHD) subjects and healthy controls in the context of a standard Go/NoGo task (visual continuous performance test [VCPT]), frequently used to measure executive functions. In contrast to many previous studies, our sample comprises children, adolescents, and adults. We analyzed data from 447 ADHD patients and 227 healthy controls. By applying multivariate linear regression analyses, we controlled the group differences between ADHD patients and controls for age and sex. As dependent variables we used behavioral (number of omission and commission errors, reaction time, and reaction time variability) and neurophysiological measures (event-related potentials [ERPs]). In summary, we successfully replicated the deviations of ADHD subjects from healthy controls. The differences are small to moderate when expressed as effect size measures (number of omission errors: d = 0.60, reaction time variability: d = 0.56, contingent negative variation (CNV) and P3 amplitudes: −0.35 < d < −0.47, ERP latencies: 0.21 < d < 0.29). Further analyses revealed no substantial differences between ADHD subtypes (combined, inattentive, and hyperactive/impulsive presentation), subgroups according to high- and low-symptomatic burden or methylphenidate intake for their daily routine. We successfully replicated known differences between ADHD subjects and controls for the behavioral and neurophysiological variables. However, the small-to-moderate effect sizes limit their utility as biomarkers in the diagnostic procedure. The incongruence of self-reported symptomatic burden and clinical diagnosis emphasizes the challenges of the present clinical diagnosis with low reliability, which partially accounts for the low degree of discrimination between ADHD subjects and controls.

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Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Behavioral and Neurophysiological Markers of ADHD in Children, Adolescents, and Adults: A Large-Scale Clinical Study

Münger

Candrian²,

Kasper³

et al. 2021

Clin EEG Neurosci

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“…Psychophysiological measures have the potential to increase diagnostic precision and enhance treatment response monitoring in ADHD (Hall et al, 2016). This potential was explored in novel studies integrating psychophysiological data with conventional CPT indices (e.g., Hemoencephalography [nirHEG], quantified electroencephalography [Q-EEG] and event-related potentials [ERP]; Areces et al, 2018; Hall et al, 2016; Muller et al, 2020). Thereby, researchers have aimed to enhance the clinical utility of CPTs as well as validate biomarkers linked to the underlying pathology of ADHD.…”

Section: Introductionmentioning

confidence: 99%

Eye Tracking During a Continuous Performance Test: Utility for Assessing ADHD Patients

et al. 2020

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Objective: The use of continuous performance tests (CPTs) for assessing ADHD related cognitive impairment is ubiquitous. Novel psychophysiological measures may enhance the data that is derived from CPTs and thereby improve clinical decision-making regarding diagnosis and treatment. As part of the current study, we integrated an eye tracker with the MOXO-dCPT and assessed the utility of eye movement measures to differentiate ADHD patients and healthy controls. Method: Adult ADHD patients and gender/age-matched healthy controls performed the MOXO-dCPT while their eye movements were monitored ( n = 33 per group). Results: ADHD patients spent significantly more time gazing at irrelevant regions, both on the screen and outside of it, than healthy controls. The eye movement measures showed adequate ability to classify ADHD patients. Moreover, a scale that combined eye movement measures enhanced group prediction, compared to the sole use of conventional MOXO-dCPT indices. Conclusions: Integrating an eye tracker with CPTs is a feasible way of enhancing diagnostic precision and shows initial promise for clarifying the cognitive profile of ADHD patients. Pending replication, these findings point toward a promising path for the evolution of existing CPTs.

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“…Psychiatric disorders are very complex because of their genetic, biological, and psychological nature, and they impair the behaviour, feelings, and cognition of an individual in a particular culture (1). Attention Deficit / Hyperactivity Disorder is one of the much common childhood psychiatric disorders characterized by persistent symptoms of inattention, impulsivity, and hyperactivity (2).…”

Section: Introduction and Objectivesmentioning

confidence: 99%

Comparison of Sensitivity to Reward and Punishment, Response Inhibition and Sustained Attention Between School Boys With Attention Deficit/Hyperactivity Disorder and Sluggish Cognitive Tempo

محمدی¹,

شادبافی²

2021

IJPCP

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Objectives: Recent studies have identified a disorder called Sluggish Cognitive Tempo (SCT) that has similarities with attention deficit / hyperactivity disorder (ADHD) in attention problems and often mistakenly labeled as ADHD. Attention problems also cause malfunctions in executive functions, often involving the hot circuit and the cold circuit. The purpose of this study was to compare the sensitivity to reward and punishment, response inhibition and sustained attention in children with ADHD and SCT. Methods: The design of the present study was in the frame of Casual Comparative. Participants comprised 100 boys (50 ADHD and 50 SCT) from elem entary schools in Tabriz in 1398-1399 academic years, which were selected through a screening method using the Child Behavior Rating Scale (SNAP-IV) and the SCT scale. Then, balloon analogue risk task (BART) was used to measure the sensitivity to reward and punishment and the continuous performance test was used to measure response inhibition and sustained attention. For data analysis Manova and SPSS 20 were used. Results: The results showed that children with ADHD had higher scores in sensitivity to reward and children with SCT had higher scores in sensitivity to punishment. Moreover, children with ADHD have deficits in response inhibition and children with SCT have deficits in sustained attention (P<0.0001). Conclusion: Based on the research Background and the findings of this study, it seems that children with SCT have deficits in hot executive circuit and children with ADHD have trouble in cold executive circuit.

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EEG/ERP-based biomarker/neuroalgorithms in adults with ADHD: Development, reliability, and application in clinical practice

Cited by 36 publications

References 32 publications

Behavioral and Neurophysiological Markers of ADHD in Children, Adolescents, and Adults: A Large-Scale Clinical Study

Behavioral and Neurophysiological Markers of ADHD in Children, Adolescents, and Adults: A Large-Scale Clinical Study

Eye Tracking During a Continuous Performance Test: Utility for Assessing ADHD Patients

Comparison of Sensitivity to Reward and Punishment, Response Inhibition and Sustained Attention Between School Boys With Attention Deficit/Hyperactivity Disorder and Sluggish Cognitive Tempo

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