EEG Low‐Voltage Alpha and Alpha Power in African American Young Adults: Relation to Family History of Alcoholism

Ehlers, Cindy L.; Phillips, Evelyn

doi:10.1097/01.alc.0000065439.09492.67

Cited by 27 publications

(25 citation statements)

References 48 publications

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“…A pronounced slow alpha decrease is associated with relapse (Saletu-Zyhlarz et al, 2004); there is an increase in slow alpha, a decrease in fast alpha, and a deceleration of the alpha centroid with six months of abstinence. On the other hand, participants who had a family history of alcoholism had significantly higher spectral power in the slow alpha frequencies (7.5–9 Hz) (Ehlers and Phillips, 2003); this was found for males with alcoholic fathers (Ehlers and Schuckit, 1991) and women at high risk for developing alcoholism (Ehlers et al, 1996). While reduced EEG alpha power in male and female offspring of alcoholics has been reported (Finn and Justus, 1999), this was not related to comorbid traits of anxiety or antisocial personality.…”

Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

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Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

“…LVA, which is characterized by an absence or very low-amplitude alpha rhythmicity, is found in 5–10% of individuals (Anokhin et al, 1992; Enoch et al, 1995). Ethnic variations may exist in the prevalence of LVA, EEG variants, and association with alcoholism or risk (Ehlers and Phillips, 2003). …”

Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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“…Another difference between studies may be that LVEEG is not highly prevalent in most populations (approximately 4% in EuroAmerican populations) [Anokhin et al, 1992; Niedermeyer, 1986] so that large scale EEG screening would be required to obtain a relatively small number of cases, leaving power for detection of variants in GWAS very low. We have previously reported that LVEEG is more prevalent in an American Indian community sample than what has been documented in other selected Asian, African, or EuroAmerican populations [Ehlers et al, 1999; Ehlers and Phillips, 2003, 2007; Ehlers et al, 2015]. We have also demonstrated that alpha EEG phenotypes in this population are substantially heritable ( h 2 = 0.62 frontal, 0.67 posterior scalp locations) [Ehlers et al, 2010b].…”

Section: Introductionmentioning

confidence: 65%

“…However studies employing multivariate genetic analyses have shown high phenotypic and genetic correlations between different frequency bands suggesting the existence of a common genetic factor that may influence overall EEG amplitude [Anokhin, 1989; Zietsch et al, 2007]. Overall EEG amplitude also shows considerable variation over different human populations and ethnic groups [Anokhin et al, 1992; Ehlers et al, 1999; Ehlers and Phillips, 2003; Ehlers et al, 2004]. One EEG pattern of overall low voltage (LVEEG) has been demonstrated to be of low prevalence in Asians and EuroAmericans [Anokhin et al, 1992], and of higher prevalence in selected African and Native American populations [Ehlers et al, 1999; Ehlers and Phillips, 2003].…”

Section: Discussionmentioning

confidence: 99%

Whole genome sequence association and ancestry‐informed polygenic profile of EEG alpha in a Native American population

Peng

Schork

Wilhelmsen

et al. 2017

American J of Med Genetics Pt B

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EEG alpha activity is the dominant oscillation in most adult humans, is highly heritable, and has been associated with a number of cognitive functions. Two EEG phenotypes, low- and high-voltage alpha (LVA & HVA), have been demonstrated to have high heritabilities. They have different prevalence depending on a population’s ancestral origins. In the present study we assessed the influence of ancestry admixture on EEG alpha power, and conducted a whole genome sequencing association analysis and an ancestry-informed polygenic study on those phenotypes in a Native American (NA) population that has a high prevalence of LVA. Seven common variants, in LD with each other upstream from gene ASIC2, reached genome-wide significance (p=2×10−8) having a positive association with alpha voltage. They had lower minor allele frequencies in the NAs than in a global population sample. Overall correlations between lower degrees of NA (higher degree European) ancestry and HVA, and higher degrees of NA and LVA were also found. Additionally a rare-variant gene-based study identified gene TIA1 being negatively associated with LVA. Approximately 3% of SNPs exhibited a 15-fold enrichment that explained nearly half of the total SNP-heritability for EEG alpha. These regions showed the most significant anti-correlations between NA ancestry and alpha voltage, and were enriched for genes and pathways mediating cognitive functions. Our findings suggested that these regions likely harbor causal variants for HVA, and lacking of such variants could explain the high prevalence of LVA in this NA population, possibly illuminating the ancestral origin and genetic basis for EEG alpha.

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“…Enoch et al reported the association between the LVEEG phenotype, anxiety disorders, and alcoholism, with the strongest association observed for a subtype of alcoholism associated with anxiety disorders (Enoch et al, 1995; Enoch et al, 1999). Finally, it should be noted that the prevalence of the LVEEG phenotype shows considerable differences across different human populations and ethnic groups (Anokhin et al, 1992; Ehlers and Phillips, 2003; Ehlers et al, 2004). This observation has important implications for association studies, since group differences in both the frequency of the phenotype and the frequency of a genetic variant can lead to spurious association (see section 6.2.2).…”

Section: Advancesmentioning

confidence: 99%

Genetic psychophysiology: Advances, problems, and future directions

Anokhin

2014

International Journal of Psychophysiology

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This paper presents an overview of historical advances and the current state of genetic psychophysiology, a rapidly developing interdisciplinary research linking genetics, brain, and human behavior, discusses methodological problems, and outlines future directions of research. The main goals of genetic psychophysiology are to elucidate the neural pathways and mechanisms mediating genetic influences on cognition and emotion, identify intermediate brain-based phenotypes for psychopathology, and provide a functional characterization of genes being discovered by large association studies of behavioral phenotypes. Since the initiation of this neurogenetic approach to human individual differences in the 1970s, numerous twin and family studies have provided strong evidence for heritability of diverse aspects of brain function including resting-state brain oscillations, functional connectivity, and event-related neural activity in a variety of cognitive and emotion processing tasks, as well as peripheral psychophysiological responses. These data indicate large differences in the presence and strength of genetic influences across measures and domains, permitting the selection of heritable characteristics for gene finding studies. More recently, candidate gene association studies began to implicate specific genetic variants in different aspects of neurocognition. However, great caution is needed in pursuing this line of research due to its demonstrated proneness to generate false-positive findings. Recent developments in methods for physiological signal analysis, hemodynamic imaging, and genomic technologies offer new exciting opportunities for the investigation of the interplay between genetic and environmental factors in the development of individual differences in behavior, both normal and abnormal.

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EEG Low‐Voltage Alpha and Alpha Power in African American Young Adults: Relation to Family History of Alcoholism

Cited by 27 publications

References 48 publications

Understanding alcohol use disorders with neuroelectrophysiology

Understanding alcohol use disorders with neuroelectrophysiology

Whole genome sequence association and ancestry‐informed polygenic profile of EEG alpha in a Native American population

Genetic psychophysiology: Advances, problems, and future directions

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