Efecto de la quimioterapia antineoplásica en pacientes con cáncer colorrectal sobre biomarcadores del estrés oxidativo y del estado redox plasmático

Abstract

en pacientes con cáncer colorrectal………………………………….. Estudio del estrés oxidativo en pacientes con cáncercolorrectal asociado al tratamiento quimioterápico……………..

Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide

“…Beside enzymes, other molecules can also act as antioxidants, such as NADPH, GSH and different vitamins, among other molecules [ 14 , 15 , 16 ]. Despite this antioxidant system, an excessive production of ROS can lead to an oxidative stress situation inducing several types of damage to different biomolecules [ 17 ]. In cancer processes, an excessive production of ROS has been related to genomic instability due to the induction of DNA damage and to the alterations in signaling pathways involved in survival, proliferation and apoptosis resistance.…”

“…In cancer processes, an excessive production of ROS has been related to genomic instability due to the induction of DNA damage and to the alterations in signaling pathways involved in survival, proliferation and apoptosis resistance. Moreover, it has been demonstrated that ROS induce vascular endothelial growth factor (VEGF) expression, producing neovascularization and fast expansion of the cancer, modifying angiogenesis and metastasis, which induce the malignancy of cancer cells [ 17 ]. The use of natural compounds with antioxidant capacity that reduce ROS levels could decrease metastatic progression [ 15 , 17 ].…”

“…Moreover, it has been demonstrated that ROS induce vascular endothelial growth factor (VEGF) expression, producing neovascularization and fast expansion of the cancer, modifying angiogenesis and metastasis, which induce the malignancy of cancer cells [ 17 ]. The use of natural compounds with antioxidant capacity that reduce ROS levels could decrease metastatic progression [ 15 , 17 ]. Furthermore, the immune defense system can be altered by ROS, since high levels of these molecules produced by NADPH oxidase can inhibit monocytes and macrophages and weaken the response of T-cells due to the down-regulation of several cytokines [ 17 ].…”

“…The use of natural compounds with antioxidant capacity that reduce ROS levels could decrease metastatic progression [ 15 , 17 ]. Furthermore, the immune defense system can be altered by ROS, since high levels of these molecules produced by NADPH oxidase can inhibit monocytes and macrophages and weaken the response of T-cells due to the down-regulation of several cytokines [ 17 ].…”