Air pollution is a global issue, and the transportation sector is recognized as the third-largest contributor to anthropogenic greenhouse gas emissions. Vehicles emit a range of chemical compounds as a direct result of the combustion process. The nature and quantity of these emissions depend on the vehicle's characteristics, road, and local weather conditions. As a result, these emissions require special attention due to the adverse effects contributing to global warming and significantly impacting human health. In this regard, diagnosing and monitoring air quality is crucial for understanding the nature and quantity of emissions generated by various sources. However, in developing countries, the necessary inputs, and data for conducting such analyses are not always available. Therefore, the purpose of this study is to estimate emissions specifically generated from road operations. To achieve this, HDM-4 calculation tool is utilized to quantitatively estimate these emissions. This tool was applied in Baja California, Mexico, on the Centinela-La Rumorosa highway. The results obtained show that annually, 372.5 tons of pollutant emissions are generated, composed of HC, CO, CO2, NOx, Par, SO2, and PB, covering a mere 128 kilometers of length within a state road network spanning 11,429 kilometers. This highlights the necessity of implementing strategies to reduce emissions or the environmental impact generated by vehicular operations on roads in developing countries.