Efectos de exposición aguda a cadmio en la acción de estrógenos en útero de rata impúber

Tchernitchin, Andrei N.; Olivares, Francisca; Aranda, Carlos; Bustamante, R; Gaete, Leonardo; Ferrada, Karla; Villagra, Rebeca; Vera, Jeanette; Iturbe, Ricardo J; Kim, Yoon A; Hernández, Natalia B; Bizjak, Tina; Novsak, Spela

doi:10.4067/s0370-41062008000400004

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…We found that the thickness of the endometrial stroma and of the myometrium was greater in the females in the vanadium group than in the animals on the control group. Uterine alterations have been related to metal exposure; Tchernitchin et al, 50 when administering cadmium (subcutaneously) to rats, observed an increase in eosinophilia and edema in the endometrium and that in the absence of estradiol, cadmium causes cellular hypertrophy in the myometrium. Our results indicate that in the vanadium group the thickness of the endometrial stroma and the myometrium increased and that it was related to the presence of inflammatory infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation

et al. 2019

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Vanadium is a metal present in particulate matter and its reprotoxic effects have been demonstrated in males and pregnant females in animal models. However, the effects of this metal on the reproductive organs of nonpregnant females have not been sufficiently studied. In a vanadium inhalation model in nonpregnant female mice, we found anestrous and estrous cycle irregularity, as well as low serum concentrations of 17β-estradiol and progesterone. A decrease in the diameter of secondary and preovulatory follicles, as well as a thickening of the myometrium and endometrial stroma, was observed in the vanadium-treated mice. There was no difference against the control group with respect to the presence of the estrogen receptor α in the uterus of the animals during the estrous stage. Our results indicate that when vanadium is administered by inhalation, effects are observed on the female reproductive organs and the production of female sex hormones.

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Section: Discussionmentioning

confidence: 99%

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation

et al. 2019

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“…This dissociation was reported under several experimental conditions in the rat uterus. 7,8,12,13 The lower incidence of breast cancer in Asian women than in western women, 14 which parallels the higher amount of phytoestrogens (including soybean products) consumed by Asian women, 14 was attributed to lifestyle but not to genetic factors. 15,16 In fact, in East and Southeast Asia, the average intake of phytoestrogens is estimated to be more than 10 times higher than in the United States or Europe, 17 and plasma isoflavone concentrations are higher in Japanese women than in Europeans.…”

Section: Introductionmentioning

confidence: 89%

Genistein Selectively Inhibits Estrogen-Induced Cell Proliferation and Other Responses to Hormone Stimulation in the Prepubertal Rat Uterus

Gaete

Tchernitchin

Bustamante

et al. 2011

Journal of Medicinal Food

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Sex hormone replacement therapy helps improve quality of life in climacteric women. However, estrogen-induced cell proliferation in the uterus and mammary gland increases the risk for cancer in these organs. The lower incidence of mammary cancer in Asian women than in western women has been attributed to high intake of soy isoflavones, including genistein. Our previous work in the prepubertal rat uterus model showed that genistein (0.5 mg/kg body weight subcutaneously) caused an estradiol-like hypertrophy in myometrial and uterine luminal epithelial cells and an increase in RNA content in luminal epithelium; however, it did not induce cell proliferation, uterine eosinophilia, or endometrial edema. The present study investigated, in the same animal model, the effect of genistein administration (0.5 mg/kg body weight subcutaneously) before treatment with estradiol-17β (0.33 mg/kg body weight subcutaneously) on uterine responses that were not induced by genistein. Pretreatment with this phytoestrogen completely inhibited estradiol-induced mitoses in uterine luminal epithelium, endometrial stroma, and myometrium and partially inhibited estradiol-induced uterine eosinophilia and endometrial edema. These findings indicate that genistein protects against estrogen-induced cell proliferation in the uterus and suggest that future studies should investigate the possibility of using this agent to decrease the risk for uterine cancer after hormone replacement therapy in climacteric women.

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“…This dissociation was reported under several experimental conditions in the rat uterus. 13,14,[19][20][21][22][23] The lower incidence of several hormonally dependent cancers in Asian women than in Western women 24 was attributed to the higher amount of diet phytoestrogensincluding soybean products-consumed by Eastern Asian women, 24,25 and suggested their possible role in breast cancer prevention. 26 For this purpose, several plant extract preparations were registered as pharmaceuticals or nutraceuticals recommended for hormone-dependent cancer prevention in climacteric women.…”

Section: Introduction Mmentioning

confidence: 99%

Daidzein–Estrogen Interaction in the Rat Uterus and Its Effect on Human Breast Cancer Cell Growth

Gaete

Tchernitchin²,

Bustamante³

et al. 2012

Journal of Medicinal Food

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Sex hormone replacement therapy provides several advantages in the quality of life for climacteric women. However, estrogen-induced cell proliferation in the uterus and mammary gland increases the risk of cancer development in these organs. The lower incidence of mammary cancer in Asian women as compared with Western women has been attributed to high intake of soy isoflavones, including genistein. We have previously shown that genistein induces an estradiol-like hypertrophy of uterine cells, but does not induce cell proliferation, uterine eosinophilia, or endometrial edema. It also inhibits estradiol-induced mitosis in uterine cells and hormone-induced uterine eosinophilia and endometrial edema. Nevertheless, genistein stimulates growth of human breast cancer cells in culture; therefore, it is not an ideal estrogen for use in hormone replacement therapy (HRD). The present study investigated the effect of another soy isoflavone, daidzein (subcutaneous, 0.066 mg/kg body weight), in the same animal model, and its effect on responses induced by subsequent treatment (1 h later) with estradiol-17b (E2; subcutaneous, 0.33 mg/kg body weight). In addition, we investigated the effects of daidzein (1 lg/mL) or E2 on the growth of human breast cancer cells in culture. Results indicate that daidzein stimulates growth of breast cancer cells and potentiates estrogen-induced cell proliferation in the uterus. We suggest caution for the use of daidzein or formulas containing this compound in HRD. Future research strategies should be addressed in the search for new phytoestrogens that selectively inhibit cell proliferation in the uterus and breast.

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Efectos de exposición aguda a cadmio en la acción de estrógenos en útero de rata impúber

Cited by 5 publications

References 32 publications

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation

Genistein Selectively Inhibits Estrogen-Induced Cell Proliferation and Other Responses to Hormone Stimulation in the Prepubertal Rat Uterus

Daidzein–Estrogen Interaction in the Rat Uterus and Its Effect on Human Breast Cancer Cell Growth

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