Efectos del estado nutricional en la enfermedad de la esclerosis múltiple: revisión sistemática

Abstract

Ródenas Esteve I, Wanden-Berghe C, Sanz-Valero J. Efectos del estado nutricional en la enfermedad de la esclerosis múltiple: revisión sistemática. ResumenObjetivo: revisar la literatura científica existente sobre los efectos del estado nutricional en la esclerosis múltiple. . La calidad de los artículos se evaluó mediante el cuestionario STROBE. Se completó la búsqueda con la consulta a expertos y la revisión de la bibliografía de los artículos seleccionados. Resultado: de las 160 referencias recuperadas, tras aplicar los criterios de inclusión y exclusión, se seleccionaron para la revisión 29 artículos. La gran mayoría de los estudios determinaron los niveles de vitamina D. Otros centraron su búsqueda en averiguar qué déficits de nutrientes podrían estar relacionados con el desarrollo de la esclerosis múltiple. Conclusiones: la vitamina D puede influir en la mejora de la esclerosis múltiple. La luz solar y la actividad física serían factores importantes, junto con el estado nutricional, en el curso de dicha enfermedad. Sería necesaria la generación de nuevos trabajos específicos que profundizaran en el tema para averiguar más acerca de la relación existente entre el estado nutricional y la esclerosis múltiple. ). The quality of the selected articles was discussed using the STROBE questionnaire. The search was completed through experts inquiry and additional review of the bibliographic references included in the selected papers. The concordance between authors (Kappa index) had to be higher than 80% for inclusion in this review. Results: Of the 160 references recovered, after applying inclusion and exclusion criteria, 29 articles were selected for review. Concordance between evaluators was 100.00%. The most studies established vitamin D levels. Others focused their research on finding out which nutrient deficits might be related to the multiple sclerosis development. Conclusions: Vitamin D may influence multiple sclerosis improvement. Sunlight and physical activity would be important factors, with nutritional status, in the course of this disease. It is necessary to produce new specific works that will delve into the subject to find out more about the relationship between nutritional status and multiple sclerosis.

Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis

“…In this regard, most of the studies that provided data used vitamin D3 [37][38][39], which appears to be more effective than vitamin D2 in increasing serum levels of 25(OH)D [58]. Finally, some studies suggest that factors such as sun exposure could act as confounding variables when determining the influence of VD on fatigue [41], since in some studies, sunlight exposure was more strongly associated with fatigue than 25(OH)D concentrations [27,59], a factor that was not considered in our study.…”

“…Vitamin D has been administered as a supplement for decades in people with MS since its deficiency can be a pathogenic risk factor and influence the activity of the disease [ 40 , 41 ]. However, to our knowledge, this is the first systematic review with meta-analysis that synthesized the effects of VD supplementation in relation to fatigue, a symptom that affects most people with this disease.…”