Efeito da hemodiluição normovolêmica aguda na coagulação sanguínea: comparação entre os testes colhidos de um modelo in vivo e de um modelo in vitro

Souza, Marco Aurélio Beloto de; Klamt, Jyrson Guilherme; Garcia, Luís Vicente

doi:10.1590/s0034-70942010000400003

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…associated parameters should be considered to minimize possible complications. 11 Previous studies have shown that the need for blood transfusion may be reduced by the use of acute normovolemic hemodilution, [12][13][14] and prophylactic intravenous administration of concentrated fibrinogen or tranexamic acid immediately before and after myocardial revascularization, which reduces the frequency of postoperative bleeding and fibrinolysis in high-risk populations. [15][16][17] Other methods such as the use of intraoperative autotransfusion in CPB cardiac surgery, hemofiltration, preoperative autologous blood donation and erythropoietin pretreatment, as well as the recognition of normovolemic anemia, have been described to reduce blood transfusion and its potential adverse effects.…”

Section: Transfusion Parametersmentioning

confidence: 99%

Transfusion of Blood Products in the Postoperative of Cardiac Surgery

Moraes¹,

Giordani²,

Borges³

et al. 2021

International Journal of Cardiovascular Sciences

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Patients undergoing cardiac surgery are prone to excessive postoperative bleeding. In addition, it is known that the passage of blood through the cardiopulmonary bypass (CPB) circuit triggers the release of inflammatory mediators, resulting in a series of changes in hemostasis.Other situations such as thrombocytopenia, disseminated intravascular coagulation, and liver failure may also influence the occurrence of acute anemia, which should be corrected immediately. 1,2 However, the indiscriminate use of blood products in cardiac surgery has been associated with increased risk of infection, increased need for mechanical ventilation, increased organ failure, longer length of hospital stay, and higher mortality rates. [3][4][5][6] Although blood transfusion may become imperative for the management of postoperative cardiac surgery patients, several efforts have been made to restrict and standardize transfusion practice and improve outcomes for patients. [7][8][9] Much has been discussed about the optimal time for transfusion, although there is no global standardization of hematocrit and hemoglobin values, but only a consensus on clinical criteria. In practice, efforts have focused on maintaining hemoglobin values between 7 and

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