DOI: 10.11606/d.9.2008.tde-27112008-100059
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Efeito das concentrações das vitaminas (séricas e da dieta) e do polimorfismo MTHFR C677T na taxa de metilação global do DNA durante o período gestacional

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Cited by 3 publications
(4 citation statements)
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“…The neural tube closure defects are congenital malformations resulting from incorrect or incomplete closure of the neural tube between the third and fourth week of embryonic development and include anencephaly, encephalopathy and spina bifida, most cases of which today are due to a lack of folic acid. [7][8][9] The low consumption in the diet, gene disorders, smoking, chronic use of oral hormonal contraceptives, diabetes, and use of anticonvulsant medications are some factors related to a decreased folic acid serum level. 10 In an attempt to reduce the problems caused by deficiency of folic acid in pregnant women, Brazil's National Health Surveillance Agency (ANVISA) made it mandatory for wheat flour and maize sold in the country to be fortified with iron and folic acid by Resolution 344 of December 12, 2002, implemented as of July 2004.…”
Section: Introductionmentioning
confidence: 99%
“…The neural tube closure defects are congenital malformations resulting from incorrect or incomplete closure of the neural tube between the third and fourth week of embryonic development and include anencephaly, encephalopathy and spina bifida, most cases of which today are due to a lack of folic acid. [7][8][9] The low consumption in the diet, gene disorders, smoking, chronic use of oral hormonal contraceptives, diabetes, and use of anticonvulsant medications are some factors related to a decreased folic acid serum level. 10 In an attempt to reduce the problems caused by deficiency of folic acid in pregnant women, Brazil's National Health Surveillance Agency (ANVISA) made it mandatory for wheat flour and maize sold in the country to be fortified with iron and folic acid by Resolution 344 of December 12, 2002, implemented as of July 2004.…”
Section: Introductionmentioning
confidence: 99%
“…Nesta situação, pode ocorrer um aumento da concentração plasmática de tHcy, levando a uma alteração do perfil de metilação no DNA (JACOB et al, 1998;FENECH et al, 1998;RAMPERSAUD et al, 2000); sendo que a metilação do DNA regula a expressão de genes, a diferenciação celular e o desenvolvimento fetal (BESTOR, 2000;PIERI et al, 2004). (KUBOTA, 2008). No entanto, este achado não foi confirmado quando se utilizou a qMSP, provavelmente em decorrência do fato do genoma ter cerca 70 a 80% das ilhas CpG metiladas, e a grande maioria destas ilhas estarem localizadas em outros locais que não as regiões promotoras de genes (RICHARDSON, 2003).…”
Section: 36unclassified
“…A cistationina, por sua vez, sofre hidrólise, formando cisteína e α-cetobutirato, também na presença de vitamina B 6 (FINKELSTEIN, 1998;SANDERS e EMERY, 2003). No estudo de Kubota (2008) (FENECH et al, 1998;JACOB et al, 1998;KLEE, 2000;CIKOT et al, 2001;LAANPERE et al, 2009). Em gestantes, o aumento de tHcy também pode ocorrer por conta de influências hormonais, hemodiluição e aumento de necessidades materno-fetal de metionina e tHcy (STEEGERS-THEUNISSEN et al 1997).…”
Section: 36unclassified
“…Os valores de P apresentados nos gráficos correspondem à comparação dos valores das variáveis segundo as idades gestacionais dentro de cada grupo. Fonte: Kubota (2008) 213 . (DRI, 1998).…”
Section: Polimorfismos Em Genes Envolvidos No Metabolismo Da Cobalaminaunclassified