Efeitos da hidroquinona sobre atividades funcionais da célula endotelial e de neutrófilos

Abstract

Hydroquinone (HQ) is a fenolic compound obtained after benzene metabolism, it is a component of cigarette, medicines, photographic developer, and it is also finding in some foods and medicinal herbs. Our research group has been shown that rats in vivo exposed to HQ present impaired leukocyte migration into lung during allergic or non-specific inflammation. In the present study, we investigate the effects of HQ on functional activities of neutrophils and endothelial cells (EC) involved in inflammation. Primary cultured EC was obtained from microcirculatory network of maleWistar rats, and treated with HQ (10 or 100 µM, two hours). After the treatments, EC was incubated in presence or absence of lipopolissacharide of E. coli (LPS; 2 µg/mL). Peritoneal neutrophils obtained four hours after local injection of oyster glycogen (10 mL, 1%) were incubated with HQ (5 or 10 µM, one hour)

Influência da Hidroquinona nas respostas imune humoral e celular induzida por vacina viral com proteína recombinante (Dengue)

“…Este último é convertido pelas enzimas do citocromo P-450, principalmente a CYP2E1, em HQ no fígado (Hedli, 1996;Inchem, 2017). Depois de absorvida, a HQ é rapidamente distribuída pela corrente sanguínea aos tecidos (Pinedo, 2009;CEFARMA, 2017;Santos et al, 2017). Lee et al, 2007) (Tabela 1).…”