Efeitos da suplementação de arginina, glutamina e ômega-3 sobre a resposta inflamatória e estado nutricional de pacientes oncológicos

Abstract

The objective of this study was to review in the literature the effects of supplementation of immunomodulatory nutrients on the nutritional therapy of cancer patients, highlighting impacts on the inflammatory response and nutritional status. The Lilacs, Scielo and PubMed databases were searched, retrieving publications from 2009 to 2019. 158 articles were found in the preliminary search and only 5.7% (n=9) were included. A positive association was found between the use of immunomodulators and an improvement in the overall condition of cancer patients in 100% (n=9) of the studies. Specifically, 55.6% (n=5) observed that supplementation of omega-3 and arginine had positive effects on the inflammatory and nutritional profile. It has been shown that omega-3 and formulas enriched with glutamine, arginine, TCM, carnitine and taurine, contributed to the maintenance of muscle mass in 22.2% (n=2) of the findings, but only in one of them did a reduction in levels of cortisol and PCR. Two other studies found that omega-3 supplementation reduced the risk of postoperative complications, and in one of them, the use of glutamine favored healing processes. It was concluded that the supplementation of arginine, glutamine and omega-3 was effective in improving the response to treatment, malnutrition and inflammatory status in cancer patients.

Effects of omega-3 and vitamin D supplementation in patients with breast cancer: a systematic review

“…The beneficial mechanisms include modulation of the inflammatory response, mitigation of cell proliferation (metastasis and angiogenesis), and a role in gene expression that drives changes in cell metabolism. In addition, omega-3 PUFAs suppress the production of COX2, through the main omega-3 fatty acids (alphalinolenic, EPA and DHA) [27,28].…”

A Review of the Nutritional Aspects and Composition of the Meat, Liver and Fat of Buffaloes in the Amazon

“…The disproportion of the n-6/n3 ratio represents a risk factor in the development of some types of cancer and cardiovascular diseases. The increased consumption of foods that provide n-3 fatty acids reduces the incidence of these diseases [ 109 , 110 ].…”

Suplementação imunomoduladora na evolução do estado nutricional e resposta imune de pacientes em tratamento oncológico: revisão integrativa

“…A partir disso, dentre as estratégias de otimização, a terapia nutricional (TN) está indicada, para diminuir a resposta metabólica ao estresse, melhorar o balanço nitrogenado e modular a resposta imunoinflamatória 7 . As propriedades da TN também são relevantes nesse caso, uma vez que estudos apontam que imunonutrientes têm mostrado benefícios no fortalecimento da resposta imunológica em pacientes oncológicos, proporcionando influência significativa no perfil bioquímico, diminuição da incidência de complicações e custo do tratamento 8 . A partir disso, o objetivo do estudo é avaliar a produção científica acerca da eficácia da suplementação imunomoduladora na manutenção do estado nutricional e inflamatório de pacientes oncológicos em tratamento quimioterápico e/ou radioterápico.…”