Efeitos das infusões de lidocaína e esmolol sobre as alterações hemodinâmicas, necessidade de analgésicos e recuperação após colecistectomia laparoscópica

Dogan, Serpil Dagdelen; Üstün, Faik Emre; Şener, Elif Bengi; Köksal, Ersin; Üstün, Yasemin Burcu; Kaya, Cengiz; Özkan, Fatih

doi:10.1016/j.bjan.2016.01.004

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Our study also shows that the postoperative pain free period was significantly more in the Group B. A systemic review on intravenous lignocaine infusion preoperatively concluded that there was a decreased anaesthetic drug requirement intraoperatively, decreased requirement of postoperative analgesics, and also had lower pain scores ( 12 ).…”

Section: Discussionsupporting

confidence: 59%

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

2018

Anesth Pain Med

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BackgroundDuring general anaesthesia, intubation of trachea and extubation of trachea are often associated with increase in haemodynamic response. Laparoscopic cholecystectomy is a minimal access surgery; postoperatively patients may experience moderate to severe pain. It is well known that lignocaine is useful in attenuating haemodynamic response to intubation and extubation. Previous studies also state that perioperative lignocaine infusion provides postoperative analgesia as well. We hypothesize that perioperative intravenous lignocaine infusion can both attenuate haemodynamic responses to intubation and extubation of trachea and also provide good postoperative analgesia in laparoscopic cholecystectomy surgeries.MethodsDouble blinded randomized controlled trial was undertaken at the department of anesthesia, Sri Siddartha medical college. In group A, 0.9% normal saline was used as placebo for perioperative intravenous infusion. In group B, preservative free 1.5 mg/kg 2 % lignocaine (Loxicard) diluted with normal saline to 1% given at 10 minutes to induction as bolus, followed by an infusion of 1.5 mg/kg/h. till 1 hour postoperatively.ResultsIn Group B there was a statistically less rise in heart rate [HR] and mean blood pressure [MBP] during intubation and extubation of trachea compared to group A. In group B there was a statistically significant increase in the mean pain free period postoperatively compared to group A.ConclusionsPerioperative intravenous infusion of lignocaine attenuates haemodynamic response during the intubation and extubation of the trachea. In addition, it also increases the mean pain free period postoperatively.

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Section: Discussionsupporting

confidence: 59%

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

2018

Anesth Pain Med

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“…Clinical studies investigating the effect of intraoperative IV lidocaine in comparison to esmolol on postoperative opioid and pain scores have shown conflicting results. Similar to our findings, Dogan et al found no difference between the two groups in postoperative 24 h opioid consumption after laparoscopic cholecystectomy [16]. In contrast, Kavak Akelma et al found significantly less fentanyl requirement in patients receiving esmolol than those receiving lidocaine infusion or placebo in the first 24 h of surgery [17].…”

Section: Discussionsupporting

confidence: 89%

“…Early recovery is one of the relevant clinical outcomes after minimally invasive surgery. It is reported that patients in esmolol group achieve early discharge criteria from the PACU as compared to lidocaine group [16]. In the same study, patients receiving lidocaine had RSS scores higher than esmolol at 10 min post-extubation.…”

Section: Discussionmentioning

confidence: 78%

“…However, the significant difference in postoperative opioid consumption was limited to the PACU stay only (standard mean difference, − 1.21; 95% CI, − 1.66 to − 0.77). Trials by Dogan et al [16] and Kavak et al [17] were not included, and perhaps inclusion of these studies might have further influenced the treatment effects. In a similar model to ours (laparoscopic cholecystectomy) [21], however, with a conventional control consisting of general anesthesia with opioids, the intraoperative fentanyl consumption was 200.5 μg in placebo group while it was null in esmolol group.…”

Section: Discussionmentioning

confidence: 99%

“…Although both lidocaine and esmolol are widely used for LC, studies comparing these agents are very few with conflicting results [16, 17]. Therefore, the primary objective of our study was to compare the effects of intraoperative lidocaine and esmolol infusion on postoperative opioid consumption and pain scores following LC.…”

Section: Introductionmentioning

confidence: 99%

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The effect of intraoperative lidocaine versus esmolol infusion on postoperative analgesia in laparoscopic cholecystectomy: a randomized clinical trial

et al. 2019

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BackgroundAs a part of multimodal analgesia for laparoscopic cholecystectomy, both intraoperative lidocaine and esmolol facilitate postoperative analgesia. Our objective was to compare these two emerging strategies that challenge the use of intraoperative opioids. We aimed to assess if intraoperative esmolol infusion is not inferior to lidocaine infusion for opioid consumption after laparoscopic cholecystectomy.MethodsIn this prospective, randomized, double-blind, non-inferiority clinical trial, 90 female patients scheduled for elective laparoscopic cholecystectomy received either intravenous (IV) lidocaine bolus 1.5 mg/kg at induction followed by an infusion (1.5 mg/ kg/h) or IV bolus of esmolol 0.5 mg/kg at induction followed by an infusion (5–15 μg/kg/min) till the end of surgery. Remaining aspect of anesthesia followed a standard protocol apart from no intraoperative opioid supplementation. Postoperatively, patients received either morphine or tramadol IV to maintain visual analogue scale (VAS) scores ≤3. The primary outcome was opioid consumption (in morphine equivalents) during the first 24 postoperative hours. Pain and sedation scores, time to first perception of pain and void, and occurrence of nausea/vomiting were secondary outcomes measured up to 24 h postoperatively.ResultsTwo patients in each group were excluded from the analysis. The postoperative median (IQR) morphine equivalent consumption in patients receiving esmolol was 1 (0–1.5) mg compared to 1.5 (1–2) mg in lidocaine group (p = 0.27). The median pain scores at various time points were similar between the two groups (p > 0.05). More patients receiving lidocaine were sedated in the post-anesthesia care unit (PACU) than those receiving esmolol (p < 0.05); however, no difference was detected later.ConclusionInfusion of esmolol is not inferior to lidocaine in terms of opioid requirement and pain severity in the first 24 h after surgery. Patients receiving lidocaine were more sedated during their stay in PACU than those receiving esmolol.Trial registrationClinicalTrials.gov- NCT02327923. Date of registration: December 31, 2014.

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Efficacy of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy: a randomized controlled trial

Sarakatsianou

Perivoliotis

Baloyiannis

et al. 2023

Langenbecks Arch Surg

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Efeitos das infusões de lidocaína e esmolol sobre as alterações hemodinâmicas, necessidade de analgésicos e recuperação após colecistectomia laparoscópica

Cited by 11 publications

References 15 publications

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

The effect of intraoperative lidocaine versus esmolol infusion on postoperative analgesia in laparoscopic cholecystectomy: a randomized clinical trial

Efficacy of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy: a randomized controlled trial

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