BackgroundThis study evaluated the effect of spray‐dried blood plasma (SDP) as a feed additive for the replacement of antibiotics in swine production. The treatments were used as strategic pulses of either antibiotics or SDP in the feed of swine during the growth and termination phases. The experimental design was conducted by 4 dietary treatments with a total of 1,456 swine selected just after leaving the nursery and evaluated for 122 days until slaughter.ResultsThe feed with the addition of the standard medication protocol (antibiotics) and without the inclusion of SDP had the highest feed intake (289.73 ± 3.04 kg) and reached a feed conversion of 2.57 ± 0.02 kg feed consumed per kg weight gained. Weight gain during the period of 0‐122 days for the treatment with three pulses of SDP with (114.12 ± 0.64 kg) and without antibiotics (114.26 ± 1.01 kg) was higher than the control treatment (111.46 ± 1.10 kg, without antibiotics and SDP). Furthermore, the antibiotic‐based treatment associated with SDP showed a 7.76% increase in weight gain when compared to the control group. Furthermore, there was a non‐significant difference in the mortality of animals and in the index for pneumonia and ulcer score.ConclusionThe application of SDP as a feed additive in swine at the growth and termination phases, combined with antibiotics, favored feed intake and weight gain and could be a promising alternative to upgrade zootechnical parameters in swine production.This article is protected by copyright. All rights reserved.