Efeitos neuroprotetores do diltiazem em coelhos com oclusão da aorta

Saba, Tonguç; Manduz, Şinasi; Sapmaz, Ismail; Tunel, Ali; Aker, Handan; Dogan, Kasim

doi:10.1590/s0102-76382007000400007

Cited by 5 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En el estudio de Saba y cols. (23), 37 conejos fueron sometido a un clampaje endoluminal de la aorta durante 30 minutos para la creación de un modelo de isquemia medular. En el grupo sin neuroprotección la tasa de paraplejia fue del 100 %, mientras que en el grupo de diltiazem intraarterial la tasa de paraparesia fue del 12,5 % (escala de Tarlov inferior a 3) a las 48 h. En el caso del grupo de Oyar y cols.…”

Section: Discussionunclassified

See 1 more Smart Citation

Animal model for assessing collateral vein sealing with energy-based devices in revascularization surgery

Espínola¹,

Andani²,

Velasco³

et al. 2023

Angiologia

View full text Add to dashboard Cite

Introduction: energy sealing devices achieve hemostasis of the vessels through the heat generated and coagulation of the vascular wall's proteins. However, mid-term efficacy for venous graft sealing in arterial bypass surgery, remains unknown Objectives: to create an animal model which allows the comparison of mid-term efficacy and safety at the sealing zone after the healing process. To compare and assess which in vivo arterial models show lower morbidity and higher survival after 4 weeks postoperative. Material and methods: an in vivo experimental study of 16 New Zealand rabbits. In each rabbit a human saphenous vein (SV) with at least one venous collateral was implanted. Two arterial models were developed: infrarrenal aorta bypass with SV (n = 5) and aortoplasty with SV patch (n = 11). In both models the collateral was randomized ad sealed with one energy sealing devices: Electrothermal Bipolar Vessel Sealing (EBVS) or Harmonic scalpel (HS). Every animal was treated with antithrombotic prophylaxis and immunosuppressive medication. Intraoperative mortality, paraplegia, infection, bleeding, and survival was analyzed. Results: two animals (50 %) survive at the 7th postoperative day in the bypass model, but anyone survived the four weeks postoperative in this model. In the aortoplasty group, seven-day survival was 55,56 % (5/9) and 4-weeks survival was 44,44 % (4/9) (p = 0.05). Paraplegia rate was 100 % for the bypass model and much lower for the patch group (25 %) (p = 0,03). Mean ischemic time was lower for the aortoplasty model (37,11 ± 8,1 min) compared to bypass group (42 ± 10,61 min) (p = 0.414). No animal presented intrabdominal hemorrhage or adverse drug reaction for immunosuppressive medication. Conclusion: aortoplasty with SV patch model has shown a lower paraplegia rate and a lower mortality at 7 days in the animal model performed. Both bypass model and patch model have shown efficacy at the sealing zone but only in the aortoplasty model four animals survived after 4 weeks.

show abstract

Section: Discussionunclassified

“…(24) se realizó el experimento en 27 conejos, con un tasa de paraplejia del 100 % en el grupo sin neuroprotección y del 75 % a las la paraparesia en aquellos animales con un tiempo de isquemia superior a 30 minutos, lo que explica la mayor tasa de complicaciones neurológicas en relación con el tiempo (23,24).…”

Section: Discussionunclassified

Animal model for assessing collateral vein sealing with energy-based devices in revascularization surgery

Espínola¹,

Andani²,

Velasco³

et al. 2023

Angiologia

View full text Add to dashboard Cite

show abstract

“…Braga Silva et al38 described a new experimental model of spinal cord injury in rats with a device for local therapeutic agents access for the study of different modifiers of the regenerative response. Saba et al39 describe the total absence of neuroprotective effects of diltiazem in rabbits with occluded aorta. Neuroprotective effects of diltiazen, Benício et al40 compared ischemic preconditioning and cerebrospinal fluid drainage as methods of spinal cord protection in dogs and found that cerebrospinal fluid drainage and immediate ischemic preconditioning seem to protect the spinal cord during descending thoracic aorta cross-clamping.…”

Section: Neurologymentioning

confidence: 99%

Recent Trends in Brazilian Medical Research. An Overview

Rocha-e-Silva¹

2009

Clinics

View full text Add to dashboard Cite

This article reviews 69 original research articles published in 6 Brazilian Medical Journals recently incorporated into the Institute for Scientific Information Journal of Citation Reports, with a view of making them comprehensively available to the readership of CLINICS within a subject category division. We expect this review to increase the visibility of a wide specter of original Brazilian research which may otherwise remain relatively unseen by the interested readershi

show abstract

Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments

Chou

Muehle

Lapchak

et al. 2017

Springer Series in Translational Stroke Research

View full text Add to dashboard Cite

Efeitos neuroprotetores do diltiazem em coelhos com oclusão da aorta

Abstract: The protective effect of diltiazem on both histopathological injury and neurological function was significant in comparison with control groups.

Cited by 5 publications

References 29 publications

Animal model for assessing collateral vein sealing with energy-based devices in revascularization surgery

Animal model for assessing collateral vein sealing with energy-based devices in revascularization surgery

Recent Trends in Brazilian Medical Research. An Overview

Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments

Contact Info

Product

Resources

About