Efek Sinergis Bahan Aktif Tanaman Obat Berbasiskan Jejaring dengan Protein Target

Abstract

Medicinal plants contain inherently active ingredients. Such ingredients are beneficial to prevent and cure diseases, as well as to perform specific biological functions. In contrast to synthetic drugs, which is based on one single chemicals, medicinal plants exert their beneficial effects through the additive or synergistic action of several chemical compounds. Those chemical compound act on single or multiple targets (multicomponent therapeutic) associated with a physiological process. Active ingredients combinations show a synergistic effect. This means that the combinational effect of several active ingredients is greater than that of individual one acting separately. A network target can be used to identify synergistic effects of plants active ingredients. The method of NIMS (Network target-based Identification of Multicomponent Synergy) is a computational approach to identify the potential synergistics effect of active ingredients. It also assessess synergistic strength of any active ingradients at the molecular level by synergy scores. We investigate these synergistic on a Jamu formula for diabetes mellitus type 2. The Jamu formula is composed of four medicinal plants, namely Tinospora crispa , Zingiber officinale, Momordica charantia, and Blumea balsamivera. Our work succesfully demonstrates that the highest synergy scores on medicinal plants synergy can be seen in pairs of several active ingredients in Zingiber officinale. On the other hand, the synergy of pairs of active ingredients in Momordica charantia and Zingiber officinale posseses a relatively high score. The same occurs in Tinospora crispa and Zingiber officinale.

Kajian Pengaruh Penyeduhan terhadap Kadar Total Fenol Teh Herbal Biji Ketumbar dan Daun Sirsak

“…Berdasarkan potensi yang dimiliki oleh daun sirsak dan biji ketumbar, maka kombinasi dari kedua bahan tersebut diharapkan dapat menghasilkan teh herbal dengan nutrisi yang tinggi, namun tetap memiliki rasa yang baik. Kedua kombinasi dilakukan untuk mengetahui apakah terjadi interaksi antara kedua bahan yang menimbulkan efek sinergis atau antagonis (Hilal A. Syahrir et al, 2016).…”

Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment

“…Parameters test Parameters are carried out using network pharmacology, which is a method that uses integrated network biological systems and computer analysis technology to ascertain the active components and mechanisms of an active ingredient with target proteins (Tjandrawinata et al, 2022). The network pharmacology is used to investigate the molecular mechanisms of tamarillo that play an essential role in reducing insulin (Hilal et al, 2016).…”