In order to better understand the complex links between infrastructure development, education, tourism, agriculture, and regional economic growth in Indonesia, this study uses structural equation modeling with partial least squares or SEM-PLS. The research makes uses of a 287-observation dataset and applies rigorous measurement model evaluation, bootstrapping analysis, structural model estimation, and model validation against multiple fit indices. The results show a strong positive correlation between each sector—agriculture, tourism, education, and infrastructure development—and regional economic expansion. The necessity for comprehensive, integrated development strategies is highlighted by the interconnectedness of these interactions. In order to promote balanced and resilient regional economic growth, the findings provide policymakers with useful insights and highlight the significance of ongoing investments in infrastructure, education, and sustainable tourism and agricultural practices.