Introduction: Low self-efficacy that occurs in chronic renal failure patients undergoing hemodialysis therapy not only has an effect on physical disorders but also has an effect on the occurrence of patient psychiatric disorders. There needs to be a scientific study on improving self-efficacy, one of which is guided by the health promotion model theory. Method: The design of this study is cross-sectional. The study sample totaled 139 respondents. The sampling technique uses executive sampling. Respondents were selected based on inclusion and exclusion criteria. The research instrument uses a questionnaire of self-efficacy, biological, psychological and sociocultural factors. The data obtained were processed using spearman rank and logistic regression. Results: This study found that biological, psychological, and sociocultural factors are associated with the self-efficacy of hemodialysis patients with a p-value = 0.000 < 0.05. Psychological factors most influence self-efficacy with p-value = 0.000 < 0.05, and biological and social factors affect self-efficacy with p-value = 0.004 < 0.005. Conclusion: Biological, Psychological and Socialcultural Factors based on the theory of health promotion model are related to selfefficacy and can affect self-efficacy in chronic renal failure patients undergoing hemodialysis therapy