Efektivitas Penggunaan Kombinasi Vitamin B pada Pasien Neuropati Diabetikum

Pinzon, Rizaldy Taslim; Sanyasi, Rosa De Lima Renita

doi:10.20473/jfiki.v5i12018.6-12

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Kombinasi vitamin B menjadi salah satu tatalaksana karena vitamin B dapat mempercepat perbaikan saraf dengan meningkatkan regenerasi sel saraf. (Rizaldy Taslim Pinzon, 2018) Penelitian ini bertujuan untuk menjelaskan bahwa vitamin B berpengaruh pada pengurangan gejala pasien neuropati diabetes melitus.…”

Section: Latar Belakangunclassified

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Pengaruh Vitamin B Pada Pasien Neuropati Diabetik

Syahrizal Syahrizal,

Aulia Rahma Asril,

Cut Putri Keumala

2023

JRIK

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Diabetes mellitus is a chronic metabolic disease that causes hyperglycemia. Diabetic neuropathy is a complication of diabetes mellitus due to hyperglycemia. People who experience diabetic neuropathy complain of tingling, numbness, stabbing pain sensations, burning pain sensations, squeezing sensations, and allodynia, which can reduce their quality of life. Administering vitamin B reduces patient symptoms and improves nerve cell function. The aim of this study was to explain the effect of vitamin B on patients with diabetic neuropathy based on a literature review. The research method used was literature review. The results of this study, based on some of the reviewed literature, found that vitamin B has an effect on reducing pain complaints in neuropathic patients with diabetes mellitus.

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Section: Latar Belakangunclassified

“…Pemberian vitamin B kombinasi ini, dapat meningkatkan QoL pasien neuropati diabetik baik dari segi fisik maupun psikis. (RizaldyTaslim Pinzon, 2018)…”

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Pengaruh Vitamin B Pada Pasien Neuropati Diabetik

Syahrizal Syahrizal,

Aulia Rahma Asril,

Cut Putri Keumala

2023

JRIK

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“…Menurut PB Perkeni tahun 2015, antikonvulsan digunakan untuk mengurangi nyeri neuropati yang disebabkan oleh komplikasi DM (53). Pemberian neurodax atau suplemen vitamin B digunakan untuk mengurangi gejala nyeri seperti seperti sensasi nyeri tertusuk, sensasi nyeri terbakar, kesemutan, dan rasa kebas pada indikasi neuropati diabetes (55). Pemberian aspirin ditujukan untuk menurunkan risiko kejadian penyakit kardiovaskular, stroke, atau infark miokard (42).…”

Section: Obat Tanpa Indikasi (C13)unclassified

Profil Drug Related Problems (DRPs) Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan Rumah Sakit Pemerintah Tipe B

Eka Puspitasari,

Sofianti Annisa,

Rahmatul Aini

et al. 2023

PJI

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Type 2 diabetes mellitus’s (DM) patients often receive polypharmacy therapy to prevent complications, but this have potential Drug Related Problems (DRPs). This study aims to determine the profile of the incidence of DRPs in type 2 DM patients, especially in the Outpatient Installation of the Government Type B Hospital in West Nusa Tenggara in 2018. This research was conducted with a cross-sectional design using secondary data with a sampling technique, namely purposive sampling. Respondents involved were type 2 DM patients with complete medical record data and have no comorbid cancer or HIV/AIDS or were pregnant. Thus, the number of respondents involved was 112 patients. The data that has been obtained was then classified into problems and causes of DRPs based on Pharmaceutical Care Network Europe Foundation Version 8.03. The results showed that 80 patients experienced DRPs with a total of 224 DRPs. The pattern of antidiabetic use in the Outpatient Installation of the Government Type B Hospital in NTB in 2018 was dominated by the Biguanide group, namely Metformin (33.85%), followed by Insulin (29.75%), and Sulfonylureas (28.21%). Insulin use was dominated by Insulin Aspart (13.33%), while Sulfonylureas were dominated by Glimepirid (25.13%). DRPs that occurred sequentially were in the category of adverse drug effects that might occur (66.52%), drugs without indications (15.63%), drugs that were not appropriate according to guidelines/formularies (7.14%), symptoms or indications not treated (4 .91%), the frequency of using the dose was insufficient (1.79%), the frequency of using the dose was too frequent (1.79%), the drug dose was too low (1.34%), too many drugs were prescribed for indications (0.45 %), and the drug dose is too high (0.45%). Based on the research, it is known that there are still DRPs in the treatment of type 2 DM patients at the Outpatient Installation of the Government Type B Hospital in NTB where the highest number of events is in the category of adverse drug effects that may occur in patients. Keywords: Antibacteria, Nimba (Azadirachta indica A.Juss), Escherichia coli, Staphylococcus aureus

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“…In silico tests are one of the studies that can predict the activity of a compound that has potential as a drug and eliminate other compounds that have low activity [15]. In silico tests have the advantage of saving energy, time, and money [16].…”

Section: Introductionmentioning

confidence: 99%

Potency of active compounds extract of soursop leaves (Annona muricata) as a candidate for cervical cancer drug in Silico

Afnani,

Emilia,

Damayanti

et al. 2024

E3S Web Conf.

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Cervical cancer is a cancer caused by an infection derived from the Human Papillomavirus (HPV) that proliferates in the cervical mucosa. Cervical cancer ranks among the two highest incidences experienced by women, with 23.4% and an average death rate of 13.9%. Vascular endothelial growth factor (VEGF) is an important protein that plays a role in the pathology of angiogenesis in tumor growth and metastasis. Various efforts have been made to minimize mortality from cervical cancer, but they have caused side effects. Indonesia is rich in a diversity of flora that has the potential to be used as a natural medicine, for example, soursop leaves (Annona muricata). The study aimed to predict the compound extract of soursop leaves as a candidate drug for cervical cancer based on a silico approach. The prediction of phytochemical properties is made based on the five laws of Lipinski as seen from the values of absorption, distribution, and metabolism with Swiss ADME. The in-silico method was conducted with the assistance of computer devices, databases, and software like Autodock, PyRx, PyMol, and Discovery Studio. The target proteins used are VEGFR1 (PDB: 3HNG) and VEGFR-2 (PDB: 3VHE). The results showed that kaempferol, sativene, and thiazole-2,4(3H,5H)-dione, 5-benzylideno-3-[(ethylphenylamino)methyl] meet the five laws of Lipinski. The compound kaempferol has the lowest binding affinity, with a value of -8.5 kcal/mol on VEGFR-1 and -10.2 kcal/mol on VEGFR-2. On the other side, sunitib interactions with VEGFR-1 were -10.0 kcal/mol and -9.4 kcal/mol, respectively. Based on the results, can be concluded that kaempferol has a high potential to be a drug candidate for cervical cancer.

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Efektivitas Penggunaan Kombinasi Vitamin B pada Pasien Neuropati Diabetikum

Cited by 3 publications

References 29 publications

Pengaruh Vitamin B Pada Pasien Neuropati Diabetik

Pengaruh Vitamin B Pada Pasien Neuropati Diabetik

Profil Drug Related Problems (DRPs) Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan Rumah Sakit Pemerintah Tipe B

Potency of active compounds extract of soursop leaves (Annona muricata) as a candidate for cervical cancer drug in Silico

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