Efektivitas Premedikasi untuk Pencegahan Reaksi Transfusi

Abstract

Latar belakang. Penggunaan premedikasi sebelum transfusi meskipun masih digunakan secara luas namun menjadi kontroversi sampai saat ini karena efektivitasnya belum diketahui dengan pasti. Tujuan. Mengetahui efektivitas pemberian premedikasi untuk mencegah reaksi transfusi. Metode. Penelusuran pustaka secara online dengan mempergunakan instrumen pencari Pubmed, Cochrane Library, dan Google. Kata kunci yang digunakan adalah "premedication","transfusion" dan "transfusion reaction". Kata kunci: tranfusi darah, premedikasi, reaksi tranfusi Evidence base case report Effectiveness of Premedication in Preventing Blood Transfusion Reaction Nadia Devina Esmeralda, Novie Amelia ChozieBackground. The use of premedication before blood transfusion is widespread. Yet the efficacy of such premedication has not been rigorously tested and still controversial. Objective. To know the effectivity of premedication in preventing blood transfusion reaction. Methods. Literature search using electronic database: Pubmed, Cochrane Library and Google with key words "premedication","transfusion" dan "transfusion reaction". Results. There are 3 articles regarding premedication prior to transfusion. Retrospective study showed that the incidence of transfusion reaction didn't significantly different by giving acetaminophen and diphenhydramine compare to placebo. Three years prospective study conclude that consumption of premedication can be reduced without increasing transfusion reaction. Cochrane Systematic review showed that allergic reaction in the premedication group had RR 1,45 (0,78-2,72) and fever reaction in this group had RR 0,52 (0,21-1,25). Conclusion. Pretransfusion medications, with any regimen, did not reduced the risk of blood transfusion reactions. Sari Pediatri 2015;17(4):312-6.