For floating liquefied natural gas (FLNG), printed circuit heat exchanger (PCHE) is an optimal choice owing to its compactness and large temperature difference heat transfer in a short time. In this study, a novel sinusoidal channel configuration was established which is with airfoil fins, and its thermal-hydraulic performance was numerically studied. The Nusselt number and Fanning friction factor were studied. Meanwhile, the effects of marine dynamic load and inlet mass flow rate (IMFR) on the novel configuration were studied by numerical simulation. Considering the application scenarios of the PCHE, the supercritical LNG (S-LNG) with 113.15 K and 32 MPa was the cold fluid, and the ethylene glycol with 293.15 K and 0.1 MPa was the hot fluid. The results show that the novel configuration has better comprehensive performance. The local turbulent kinetic energy of the novel configuration is improved by about 19.78%. The temperature and velocity uniformity are improved. Marine dynamic load deteriorates the comprehensive performance of the novel configuration. With the increasing of the IMFR, the outlet temperature for S-LNG gradually decreases from 240.65 K to 186.70 K, while the pressure drop and turbulent kinetic energy increase from 6969.72 Pa to 23225.75 Pa and 0.0256 m2/s2 to 0.12874 m2/s2, respectively. This work can provide valuable guidance for PCHE under cryogenic and supercritical pressure working condition in engineering applications.