Effect and Correlation of Rosa roxburghii Tratt Fruit Vinegar on Obesity, Dyslipidemia and Intestinal Microbiota Disorder in High-Fat Diet Mice

Abstract

To investigate the effect of Rosa roxburghii Tratt fruit vinegar (RFV) on the intervention of obesity and hyperlipidemia and its potential mechanism, a high-fat diet (HFD)-induced obesity model in mice was established and gavaged with RFV, saline and xuezhikang for 30 consecutive days, respectively. The results showed that RFV supplementation significantly reduced fat accumulation, and improved dyslipidemia and liver inflammation in HFD mice. RFV intervention for 30 days significantly improved the diversity of gut microbiota and altered the structure of gut microbiota in HFD mice. Compared with the model group (MC), the ratio of Firmicutes to Bacteroidetes at least decreased by 15.75% after RFV treatment, and increased the relative abundance of beneficial bacteria (Proteobacteria, Bacteroidetes, Lactobacillaceae, Bacteroides, Akkermansia,) and decreased the relative abundance of harmful bacteria (Ruminococcaceae, Erysipelotrichaceae, Ruminococcaceae _UCG-013, Lachnospiraceae, Allobaculum, Actinobacteria). Spearman’s correlation analysis revealed that Erysipelotrichaceae, Allobaculum, Lachnospiraceae, Ruminococcaceae, Ruminococcaceae_UCG-013, uncultured_bacterium_f_Lachnospiraceae and Desulfobacterota were positively correlated (p < 0.05) with the body weight of mice, while Proteobacteria was negatively correlated (p < 0.05) with the body weight of mice. The two main bacteria that could promote dyslipidemia in obese mice were Actinobacteria and Firmicutes, while those that played a mitigating role were mainly Bacteroidetes. It is concluded that RFV plays an important role in the intervention of obesity and related complications in HFD mice by regulating their gut microbiota.

Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice

“…When compared to the NC group, the intestinal tracts of the mice given a high-fat diet had fewer Lachnospiraceae and more Desulfovibrionaceae and Prevotellaceae, which is consistent with studies in the literature [17,34]. Lachnospiraceae are involved in carbohydrate metabolism, fermenting acetic and butyric acids to provide energy for the host [36,37]. Inflammatory disorders had a positive correlation with prevotellaceae [38], and Desulfovibrionaceae belongs to the genus of harmful intestinal Bacteria, which was positively associated with the indicators of hyperlipidemia in the body [39].…”

Deciphering the mechanism of jujube vinegar on hyperlipoidemia through gut microbiome based on 16S rRNA, BugBase analysis, and the stamp analysis of KEEG

“…Peptostreptococcaceae plays a role in atherosclerosis (60). The relative abundance of Ruminococcaceae decreased in the vinegar group, consistent with Li et al (61). Akkermansia is a Gram-negative bacterium belonging to the Verrucomicrobacteria, which produces mucin-degrading enzymes that ferment mucin to acetate, propionate and sulfate (62), according to clinical and preclinical studies, Akkermansia was found to be negatively associated with metabolic disorders (63)(64)(65).…”

Ameliorating the effect and mechanism of chitosan oligosaccharide on nonalcoholic fatty liver disease in mice

“…It is in negative correlation with BMI, waist circumference, TG and other factors related to obesity or signs of metabolic disorder. 30 As shown in Fig. 4(h), the Desulfobacterota in the model group was significantly reduced compared with the control group, but COST could significantly improve the Desulfobacterota content and reverse the structural changes of the gut microbiota induced by HFD.…”