Effect and fate of orally administered lactic acid in rats.

Morotomi, Masami; Sakai, Kosei; Yazawa, Kazunaga; Suegara, Nobuo; Kawai, Yasuo; Mutai, Masahiko

doi:10.3177/jnsv.27.117

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Two hours after the lactate administration, blood lactate level significantly increased up to 4.1 ± 0.3 mmol/L. Similar to this observation, the oral administration of lactic acid to rats led to a rise in the blood level [24].…”

Section: Methodsmentioning

confidence: 63%

Lactate Stimulates a Potential for Hypertrophy and Regeneration of Mouse Skeletal Muscle

et al. 2019

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The effects of lactate on muscle mass and regeneration were investigated using mouse skeletal muscle tissue and cultured C2C12 cells. Male C57BL/6J mice were randomly divided into (1) control, (2) lactate (1 mol/L in distilled water, 8.9 mL/g body weight)-administered, (3) cardio toxin (CTX)-injected (CX), and (4) lactate-administered after CTX-injection (LX) groups. CTX was injected into right tibialis anterior (TA) muscle before the oral administration of sodium lactate (five days/week for two weeks) to the mice. Oral lactate administration increased the muscle weight and fiber cross-sectional area, and the population of Pax7-positive nuclei in mouse TA skeletal muscle. Oral administration of lactate also facilitated the recovery process of CTX-associated injured mouse TA muscle mass accompanied with a transient increase in the population of Pax7-positive nuclei. Mouse myoblast-derived C2C12 cells were differentiated for five days to form myotubes with or without lactate administration. C2C12 myotube formation with an increase in protein content, fiber diameter, length, and myo-nuclei was stimulated by lactate. These observations suggest that lactate may be a potential molecule to stimulate muscle hypertrophy and regeneration of mouse skeletal muscle via the activation of muscle satellite cells.

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Section: Methodsmentioning

confidence: 63%

Lactate Stimulates a Potential for Hypertrophy and Regeneration of Mouse Skeletal Muscle

et al. 2019

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“…Most animals tolerate a daily dose of more than 1500 mg lactic acid per kg bodyweight (Holten, Mueller & Rehbinder, 1971). In rats, absorption of 1950 mg DL lactic acid per kg bodyweight resulted only in a slight, transient hyperlactataemia and a slight decrease of blood pH (Morotomi et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Effect of lactic acid treatment during processing on the sensory quality and lactic acid content of fresh broiler chickens

Marel

Vries

Logtestijn

et al. 1989

Int J of Food Sci Tech

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Microbial decontamination by lactic acid treatment during processing of fresh broiler chickens is an effective way to produce a safer product with good keeping quality. It remained to be assessed whether such a treatment adversely affects the organoleptic quality of the product. Lactic acid treatment results in an increased acid concentration in the skin, with no increase in lactic acid concentration in the underlying muscle tissue. Differences in sensory quality were only found in appearance of the carcasses, the controls being identified as discoloured. A preference test did not show any difference in lactic acid treated and untreated grilled legs.

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“…Compared to endogenously produced lactic acid, the lactic acid consumed from the FWC will have a substantially different biodistribution, as it is subjected to the multitude of digestive processes all along the human gastrointestinal tract. In particular, the initial stages of exogenous lactate digestion (absorption and distribution) will differ to endogenous lactate, which is directly released from the human cell into circulation (52,53). In healthy adults, plasma lactate is primarily cleared by the liver and mitochondria-rich tissue, such as skeletal muscle (54,55).…”

Section: Discussionmentioning

confidence: 99%

Daily Fermented Whey Consumption Alters the Fecal Short-Chain Fatty Acid Profile in Healthy Adults

et al. 2020

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Gut microbiota influences many aspects of host health including immune, metabolic, and gut health. We examined the effect of a fermented whey concentrate (FWC) drink rich in L-(+)-Lactic acid, consumed daily, in 18 healthy men (n = 5) and women (n = 13) in free-living conditions. Objective: The aims of this 6-weeks pilot trial were to (i) identify changes in the gut microbiota composition and fecal short chain fatty acid (SCFA) profile, and (ii) to monitor changes in glucose homeostasis. Results: Total fecal SCFA (mM) concentration remained constant throughout the intervention. Proportionally, there was a significant change in the composition of different SCFAs compared to baseline. Acetate levels were significantly reduced (−6.5%; p < 0.01), coupled to a significant increase in the relative amounts of propionate (+2.2%; p < 0.01) and butyrate (+4.2%; p < 0.01), respectively. No changes in the relative abundance of any specific bacteria were detected. No significant changes were observed in glucose homeostasis in response to an oral glucose tolerance test. Conclusion: Daily consumption of a fermented whey product led to significant changes in fecal SCFA metabolite profile, indicating some potential prebiotic activity. These changes did not result in any detectable differences in microbiota composition. Post-hoc analysis indicated that baseline microbiota composition might be indicative of participants likely to see changes in SCFA levels. However, due to the lack of a control group these findings would need to be verified in a rigorously controlled trial. Future work is also required to identify the biological mechanisms underlying the observed changes in microbiota activity and to explore if these processes can be harnessed to favorably impact host health. Clinical Trial Registration: www.clinicaltrials.gov, identifier NCT03615339; retrospectively registered on 03/08/2018.

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Effect and fate of orally administered lactic acid in rats.

Cited by 5 publications

References 11 publications

Lactate Stimulates a Potential for Hypertrophy and Regeneration of Mouse Skeletal Muscle

Lactate Stimulates a Potential for Hypertrophy and Regeneration of Mouse Skeletal Muscle

Effect of lactic acid treatment during processing on the sensory quality and lactic acid content of fresh broiler chickens

Daily Fermented Whey Consumption Alters the Fecal Short-Chain Fatty Acid Profile in Healthy Adults

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