Effect and mechanism of pearl on ovarian function of rats with premature ovarian failure induced by tripterygium glycosides

Exploring the effect of Gouqi Nuzhen Liuhe decoction on the PI3K/mTOR signaling pathway for premature ovarian insufficiency based on system pharmacology

“…Cuscutae Semen is predominantly utilized for treating female conditions such as infertility, premature ovarian failure, and recurrent miscarriage [ 46 ]. Current research indicates that the main active substances of Cuscutae Semen, total flavonoids, and quercetin can partially enhance ovarian function in a Tripterygium wilfordii-induced premature ovarian failure model [ 47 ]. Wang et al highlighted the significant restorative effects of Cuscuta chinensis total flavonoids on rats with chemotherapy-induced premature ovarian failure, leading to increased ovarian weight and follicle numbers, elevated estrogen levels, and notable therapeutic effects on premature ovarian failure [ 48 ].…”