Effect and safety of labor epidural analgesia with intermittent boluses of 0.1% bupivacaine with fentanyl on fetal and maternal outcomes and wellbeing

Introduction: 725 Discussion: 1251 Abbreviations: AAFE, absolute average fold error; AUC, area under the plasma concentrationtime curve; B/P ratio, blood-to-plasma ratio; C max , peak plasma concentration; CL int,u , unbound hepatic intrinsic clearance; CL r , renal clearance; C ss , steady-state concentration; CYP3A7, cytochrome P450 3A7; ER, hepatic extraction ratio; FLM, fetal liver microsomes; f u , fraction unbound in plasma; GFR, glomerular filtration rate; HPLC-MS/MS, high performance liquid chromatography with tandem mass spectrometry; IV, intravenous; K p , tissue partitioning coefficients; MA, maternal artery; mf-PBPK model, maternal-fetal physiologically-based pharmacokinetic model; MV, maternal vein; t max , time to reach C max ; UV, umbilical vein; UA, umbilical artery; V ss , steady-state volume of distribution;

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Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling

Shum

Shen

Isoherranen

2021

Drug Metab Dispos

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Analysis of the Clinical Effect of Music Combined with Hypnosis on Labor Analgesia Based on Data Mining

Chen

Wang

et al. 2021

Journal of Healthcare Engineering

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The objective of this paper is to study the curative effect of music combined with hypnosis on labor pains during childbirth. Based on the algorithm of data mining, we randomly selected 100 women who delivered babies in obstetric units from October 2020 to June 2021, set the control group and the observation group, obtained the relevant clinical data through comparison, and analyzed the value of music combined with hypnotic analgesia midwifery in obstetrics. The results showed that the number of spontaneous delivery cases in the observation group was higher than that in the control group ( P < 0.05 ) and the delivery time in the observation group was better than that in the control group ( P < 0.05 ). It is proved that music combined with hypnosis can effectively improve the rate of natural childbirth and shorten the overall labor time, so as to guarantee the health of mother and child.

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Effect and safety of labor epidural analgesia with intermittent boluses of 0.1% bupivacaine with fentanyl on fetal and maternal outcomes and wellbeing

Cited by 2 publications

References 20 publications

Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling

Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling

Analysis of the Clinical Effect of Music Combined with Hypnosis on Labor Analgesia Based on Data Mining

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