Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

Abstract

Helminths disease is one of the infectious diseases caused by the entry of parasites in the form of worm eggs into the human body through the human digestive tract due to pollution through the soil-transmitted helminth (STH). This study measured the in vitro effect of Areca catechu ethanol extract partitioning as anthelmintic against Ascaris lumbricoides worms using a 125 mg pyrantel pamoate control. The test animals used were living and mobile worms of A. lumbricoides, which were taken from the small intestines of pigs. The study group was divided into 5 groups, namely positive control (pyrantel pamoate ) 125 mg), negative control (0.9% NaCl solution) and ethanol extract group A. catechu 10%, 20%, 30%. The results confirmed that the ethanol extract partition of A. catechu at exposure to a concentration of 30% showed a high level of efficacy in killing worms with an average time of death of A. lumbricoides worms at 6 to 12 hours compared to pyrantel pamoat solution. However, at exposure to concentration, 10% and 20% obtained a slightly longer average mortality time of 8 to 24 hours, respectively. Partitioning of A. catechu ethanol extract at a concentration of 30% showed the highest level of efficacy in killing A. lumbricoides worms based on average faster mortality time than the concentrations of 10% and 20% collected. Ethanol extract A. catechu has pharmacological therapeutic effects have various properties, including can be used for the treatment of diseases caused by parasites and also several other diseases.