Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

Hou, Jian; Huang, Chao; Zhu, Bo; Liu, Wei; Zhu, Qingqing; Wang, Lu; Li, Tian; Yuan, Caiyan; Lai, Shao-yang; Wu, Desheng; Zhu, Feiqi; Zhang, Jiafei; Huang, Jia; Gao, Erwei; Huang, Yi-dan; Nie, Lulin; Lu, Shaoyou; Yang, Xifei; Zhou, Li; Ye, Fang; Yuan, Jing; Liu, Jianjun

doi:10.1007/s11356-022-22392-3

Cited by 2 publications

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“…These contrary results may have the following reasons: first, nicotine has multiple metabolites, which have different effects on cognitive ability. Recent studies reported that nicotine metabolites HyPyBut or NicGluc are positively associated with cognitive performance 12 , 29 . In this study, CNO and NicGluc showed a trend of cognitive protection, although not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Childhood tobacco smoke exposure can have sustained negative effects on cognitive function and brain structure 25,26 , and even affect cognitive ability in middle age 27 . Aging-related environmental tobacco smoke exposure is associated with poorer cognitive performance 28,29 . However, nicotine can improve cognitive performance in MCI patients and is also found in non-smokers [30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

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Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Huang,

Ren,

et al. 2023

Tob. Induc. Dis.

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INTRODUCTION This study comprehensively assessed the association between eight metabolites of urinary nicotine and cognitive impairment. METHODS This cross-sectional study was based on the data of Shenzhen Aging Related Disorder Cohort (SADC), including 51 elderly community data variables such as demographic characteristics, neuropsychological assessment and environmental factors, from July 2017 to November 2018. Participant’s cognitive function was assessed by Mini-Mental State Examination (MMSE) scale and urinary nicotine metabolite [including cotinine N-β-D-glucuronide (CotGluc), rac 4-hydroxy-4-(3-pyridyl) butanoic acid dicyclohexylamine salt (HyPyBut), trans-3’-hydroxy cotinine O-β-D-glucuronide (OHCotGluc), and cotinine (Cot), etc.] concentrations were measured by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Generalized linear models and restricted cubic spline models were used to explore the relationships between the urinary levels of nicotine metabolite and cognitive function. RESULTS A total of 296 individuals aged >60 years were included. Individuals in the third quartile of CotGluc had a 0.786 point (95% CI: -1.244 – -0.329) decrease or in the highest quartile of OHCotGluc had a 0.804 point (95% CI: -1.330 – -0.278) decreased in attention and calculation compared to those in the lowest quartile (all p for trend <0.05). Compared with those in the lowest quartile, individuals in the highest quartile of CotGluc, HyPyBut, OHCotGluc and Cot, respectively, corresponded to a 1.043 point (95% CI: -2.269–0.182), 1.101 points (95% CI: -2.391–0.188), 2.318 points (95% CI: -3.615 – -1.020), and 1.460 points (95% CI: -2.726 – -0.194) decreased in MMSE total score (all p for trend <0.05). A non-linear dose-response relationship between urinary levels of CotGluc, HyPyBut, OHCotGluc or Cot and cognitive function (all overall p<0.05, non-linear p<0.05). Subgroup analysis showed that urinary levels of CotGluc, OHCotGluc or Cot were significantly negatively associated with cognitive function (all p for trend <0.05) among females and non-smokers. CONCLUSIONS The findings highlight the public health implications of environmental tobacco smoke exposure, and effective interventions need to be performed for vulnerable populations.

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Section: Discussionmentioning

confidence: 99%