Effect modification of perinatal exposure to air pollution and childhood asthma incidence

Lavigne, Éric; Bélair, Marc‐André; Duque, Daniel Rodriguez; Minh, T.; Stieb, David M.; Hystad, Perry; Donkelaar, Aaron van; Martin, Randall V.; Crouse, Dan L.; Crighton, Eric; Chen, Hong; Burnett, Richard T.; Weichenthal, Scott; Villeneuve, Paul J.; To, Teresa; Brook, Jeffrey R.; Johnson, Markey; Cakmak, Sabit; Yasseen, Abdool S.; Walker, Mark

doi:10.1183/13993003.01884-2017

Cited by 75 publications

(78 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We applied a temporal adjustment to the satellite-derived PM2.5 estimates and LUR NO2 model in order to more precisely identify exposures on a weekly basis during pregnancy and monthly basis during childhood (18). A ratio was calculated based on weekly mean PM2.5 and NO2 concentrations at each ground monitor location in the City of Toronto to the long term satellite-derived and LUR model estimated concentrations for each of these monitor locations.…”

Section: Exposure Assessment For Ambient Air Pollutantsmentioning

confidence: 99%

“…We used information available from health administrative databases to extract the following individual-level covariates, based on prior literature (10,12,18): birth weight, infant sex, gestational age (in weeks), maternal age at delivery (< 20, 20-34, ≥ 35 or missing), maternal cigarette smoking anytime during pregnancy (yes, no or missing), parity (0, 1, ≥ 2), maternal breastfeeding intentions on discharge (yes, no or missing), maternal history of asthma (33) and season of birth ((winter (January to March), spring (April to June), summer (July to September) and fall (October to December)). Since we did not have individual-level socioeconomic status Finally, we obtained estimates of exposure to green space at the residential location during pregnancy using the Normalized Difference Vegetation Index (NDVI).…”

Section: Covariatesmentioning

confidence: 99%

“…Since the greenness measures were available as annual averages for each postal code, we calculated the weighted average of exposure during pregnancy using consecutive years. The NDVI has been used in prior epidemiological studies focusing in the pregnancy period (18,45).…”

Section: Covariatesmentioning

confidence: 99%

“…The prevalence of asthma in children has been increasing worldwide over the last decades (1)(2)(3). Evidence links ambient air pollution exposures during pregnancy and early life with lung function deficits in children (4-7) as well as childhood asthma incidence (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). While most studies have focused on traffic-related air pollutants such as nitrogen oxides (NOx) and particulate matter (PM), there is still considerable uncertainty as to whether these pollutants are primarily responsible for the observed adverse effects.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma

Lavigne¹,

Donelle

Hatzopoulou³

et al. 2019

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

Word count: 3490At a Glance Commentary: Scientific Knowledge on the Subject: Ambient fine particulate matter (PM2.5) exposure in utero has been associated with the development of childhood asthma. However, little is known regarding the impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood asthma development What this Study Adds to the Field: Our findings suggest that UFPs exposure during the second trimester of pregnancy was associated with an increased risk of developing asthma in children before age 6 independent of other air pollutants including NO2 and PM2.5. These findings highlight the need for further research on the effects of UFPs during the perinatal period on respiratory health in children. Online Data Supplement: This article has an online data supplement, which is accessible from this issue's table of content online at www.atsjournls.org 1 ABSTRACT Rationale: Little is known regarding the impact of ambient ultrafine particles (<0.1 μm) (UFPs) on childhood asthma development. Objective: To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma. Methods: A total of 160,641 singleton live births occurring in the City of Toronto, Canada between April 1 st 2006and March 31 st 2012 were identified from a birth registry. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using random-effects Cox proportional hazards models, adjusting for personal-and neighborhood-level covariates. We investigated both single-and multi-pollutant models accounting for co-exposures to PM2.5 and NO2. Measurements and Main Results: We identified 27,062 children with incident asthma diagnosis during the follow-up. In adjusted models, second trimester exposure to UFPs (Hazard Ratio (HR) per interquartile (IQR) increase = 1.09, 95% CI: 1.06 -1.12) was associated with asthma incidence. In models additionally adjusted for PM2.5 and NO2, UFPs exposure during the second trimester of pregnancy remained positively associated with childhood asthma incidence (HR per IQR increase = 1.05, 95% CI: 1.01 -1.09). Conclusion: This is the first study to evaluate the association between perinatal exposure to UFPs and the incidence of childhood asthma. Exposure to UFPs during a critical period of lung development was linked to the onset of asthma in children, independent of PM2.5 and NO2. Abstract word count: 229

show abstract

Section: Exposure Assessment For Ambient Air Pollutantsmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma

Lavigne¹,

Donelle

Hatzopoulou³

et al. 2019

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…The multifactorial aetiology of child asthma begins with the mother. Maternal asthma, and exposure to cigarette smoke and air pollution in pregnancy are among the factors known to increase offspring risk for asthma [7,8]. Preterm birth and low birth weight have also been associated with asthma risk [9].…”

mentioning

confidence: 99%

Maternal antibiotic use and child asthma: is the association causal?

2018

View full text Add to dashboard Cite

show abstract

Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China

Zhang

Wei

et al. 2022

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceExposure to particulate matter (PM) has been associated with childhood asthma and wheeze. However, the specific associations between asthma and PM with an aerodynamic equivalent diameter of 1 μm or less (ie, PM1), which is a contributor to PM2.5 and potentially more toxic than PM2.5, remain unclear.ObjectiveTo investigate the association of early-life (prenatal and first year) exposure to size-segregated PM, including PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10, with childhood asthma and wheeze.Design, Setting, and ParticipantsThis cross-sectional study was based on a questionnaire administered between June 2019 and June 2020 to caregivers of children aged 3 to 6 years in 7 Chinese cities (Wuhan, Changsha, Taiyuan, Nanjing, Shanghai, Chongqing, and Urumqi) as the second phase of the China, Children, Homes, Health study.ExposuresExposure to PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10 during the prenatal period and first year of life.Main Outcomes and MeasuresThe main outcomes were caregiver-reported childhood asthma and wheeze. A machine learning–based space-time model was applied to estimate early-life PM1, PM2.5, and PM10 exposure at 1 × 1-km resolution. Concentrations of PM1-2.5 and PM2.5-10 were calculated by subtracting PM1 from PM2.5 and PM2.5 from PM10, respectively. Multilevel (city and child) logistic regression models were applied to assess associations.ResultsOf 29 418 children whose caregivers completed the survey (15 320 boys [52.1%]; mean [SD] age, 4.9 [0.9] years), 2524 (8.6%) ever had wheeze and 1161 (3.9%) were diagnosed with asthma. Among all children, 18 514 (62.9%) were breastfed for more than 6 months and 787 (2.7%) had parental history of atopy. A total of 22 250 children (75.6%) had a mother with an educational level of university or above. Of the 25 422 children for whom information about cigarette smoking exposure was collected, 576 (2.3%) had a mother who was a current or former smoker during pregnancy and 7525 (29.7%) had passive household cigarette smoke exposure in early life. Early-life PM1, PM2.5, and PM10 exposure were significantly associated with increased risk of childhood asthma, with higher estimates per 10-μg/m3 increase in PM1 (OR, 1.55; 95% CI, 1.27-1.89) than in PM2.5 (OR, 1.14; 95% CI, 1.03-1.26) and PM10 (OR, 1.11; 95% CI, 1.02-1.20). No association was observed between asthma and PM1-2.5 exposure, suggesting that PM1 rather than PM1-2.5 contributed to the association between PM2.5 and childhood asthma. There were significant associations between childhood wheeze and early-life PM1 exposure (OR, 1.23; 95% CI, 1.07-1.41) and PM2.5 exposure (OR, 1.08; 95% CI, 1.01-1.16) per 10-μg/m3 increase in PM1 and PM2.5, respectively.Conclusions and RelevanceIn this cross-sectional study, higher estimates were observed for the association between PM with smaller particles, such as PM1, vs PM with larger particles and childhood asthma. The results suggest that the association between PM2.5 and childhood asthma was mainly attributable to PM1.

show abstract

Effect modification of perinatal exposure to air pollution and childhood asthma incidence

Cited by 75 publications

References 47 publications

Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma

Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma

Maternal antibiotic use and child asthma: is the association causal?

Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China

Contact Info

Product

Resources

About