Effect of 1,25-dihydroxycholecalciferol on sarcoplasmic reticulum calcium transport in strontium-fed chicks

Boland, Ricardo; Boland, Ana Russo de; Ritz, Eberhard; Hasselbach, Wilhelm

doi:10.1007/bf02405030

Cited by 31 publications

(10 citation statements)

References 30 publications

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“…Data on the in vivo effects of vitamin D3 and derived metabolites on muscle have shown their involvement in Ca movements across intracellular and plasma membranes, lending support to this interpretation. 1,25-dihydroxycholecaciferol has been shown to affect Ca uptake and release by the sarcoplasmic reticulum [11,12]. Previous administration of vitamin D3 to vitamin Ddeficient animals produces an increase in the uptake [23] and effiux [24] of calcium from isolated mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D3 metabolites on calcium fluxes in intact chicken skeletal muscle and myoblasts culturedin vitro

Giuliani

Boland

1984

Calcif Tissue Int

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25-hydroxycholecalciferol (25OHD3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) at physiological concentrations exerted direct effects on Ca fluxes in cultured vitamin D-deficient chick soleus muscle and myoblasts. Isotopic desaturation curves of soleus muscle prelabeled with 45Ca indicated that the action of 25OHD3 is localized in a slow-exchangeable Ca pool where it stimulates net Ca uptake. On the other hand, the predominant effects of 1,25(OH)2D3 consist in an increase of the rate constant of Ca efflux of this pool and in an increase of net Ca uptake in a fast-exchangeable pool. 24,25-dihydroxycholecalciferal proved to be inactive on both Ca uptake and efflux. In addition, 1,25(OH)2D3 significantly increased 45Ca labeling of cultured chick myoblasts. These effects were accompanied by changes in the growth and differentiation of the cultures. The results suggest a direct involvement in vivo of 25OHD3 and 1,25(OH)2D3 on muscle cellular calcium.

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Section: Discussionmentioning

confidence: 99%

Effects of vitamin D3 metabolites on calcium fluxes in intact chicken skeletal muscle and myoblasts culturedin vitro

Giuliani

Boland

1984

Calcif Tissue Int

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“…In the latter study, a reduction in the rate of relaxation of skeletal muscle of the same animals after tetanic stimulation was also shown. Abnormal muscle function in uremia may also be related to impaired Ca transport by SR as indicated by decreased Ca uptake in SR vesicles obtained from nephrectomized rabbits (65) or strontiumfed chicks (66). 1,25-(OH) 2 D may be the metabolite involved in SR function as dosage of the animals with the sterol reversed these changes (20,66).…”

Section: Studies In Vivomentioning

confidence: 96%

Role of Vitamin D in Skeletal Muscle Function*

1986

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“…1,25(OH) 2 D seems to be responsible for the active transportation of Ca 2+ into sarcoplasmatic reticulum (SR) by Ca-ATPase [42]. Thereby, the activity of the CaATPase is regulated by 1,25(OH) 2 D-stimulated phosphorylation of proteins in the SR membrane [41].…”

Section: Osteomalacic Myopathymentioning

confidence: 99%

Vitamin D and Muscle Function

Pfeifer¹,

Begerow²,

Minne³

2002

Osteoporos Int

449

267

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The aim of this review is to summarize current knowledge on the relation between vitamin D and muscle function. Molecular mechanisms of vitamin D action on muscle tissue have been known for many years and include genomic and non-genomic effects. Genomic effects are initiated by binding of 1,25-dihydroxyvitamin D3 (1,25(OH)2D) to its nuclear receptor, which results in changes in gene transcription of messenger RNA and subsequent protein synthesis. Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR). Genetic variations in the VDR and the importance of VDR polymorphisms in the development of osteoporosis are still a matter of controversy and debate. Most recently, VDR polymorphisms have been described to affect muscle function. The skin has an enormous capacity for vitamin D production and supplies the body with 80-100% of its requirements of vitamin D. Age, latitude, time of day, season of the year and pigmentation can dramatically affect the production of vitamin D in the skin. Hypovitaminosis D is a common feature in elderly people living in northern latitudes and skin coverage has been established as an important factor leading to vitamin D deficiency. A serum 25-hydroxyvitamin D level below 50 nmol/l has been associated with increased body sway and a level below 30 nmol/l with decreased muscle strength. Changes in gait, difficulties in rising from a chair, inability to ascend stairs and diffuse muscle pain are the main clinical symptoms in osteomalacic myopathy. Calcium and vitamin D supplements together might improve neuromuscular function in elderly persons who are deficient in calcium and vitamin D. Thus 800 IU of cholecalciferol in combination with mg of elemental calcium reduces hip fractures and other non-vertebral fractures and should generally be recommended in individuals who are deficient in calcium and vitamin D. Given the strong interdependency of vitamin D deficiency, low serum calcium and high levels of parathyroid hormone, however, it is difficult to identify exact mechanisms of action.

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Effect of 1,25-dihydroxycholecalciferol on sarcoplasmic reticulum calcium transport in strontium-fed chicks

Cited by 31 publications

References 30 publications

Effects of vitamin D3 metabolites on calcium fluxes in intact chicken skeletal muscle and myoblasts culturedin vitro

Effects of vitamin D3 metabolites on calcium fluxes in intact chicken skeletal muscle and myoblasts culturedin vitro

Role of Vitamin D in Skeletal Muscle Function*

Vitamin D and Muscle Function

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