Effect of 1,25-(OH)2D3 on jejunal absorption of magnesium in patients with chronic renal disease

Schmulen, A. Carl; Lerman, Michael I.; Pak, Charles Y.C.; Zerwekh, Joseph E.; Morawski, Stephen G.; Fordtran, John S.; Vergne-Marini, P.

doi:10.1152/ajpgi.1980.238.4.g349

Cited by 24 publications

(23 citation statements)

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“…Interestingly, variations in magnesium intake have been reported not to influence magnesium absorption when studied by in situ perfusion in rats (23). Our results support the above scheme for the intestinal adaptation process involving 1,25-(OH)2-D, since we have previously shown that this vitamin D metabolite stimulates magnesium absorption in anephric humans (8).…”

Section: Discussionsupporting

confidence: 89%

Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

Norman¹,

Fordtran²,

Brinkley³

et al. 1981

J. Clin. Invest.

105

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A B S T R A C T Previous balance studies have shown that fractional calcium absorption is increased by a low and reduced by a high calcium diet. The present studies were done to determine which segment of the small intestine is most sensitive to alterations in dietary calcium, and to see if dietary calcium intake has an effect on the intestinal absorption of another divalent cation, magnesium. Absorption was measured during constant perfusion of 30-cm segments ofjejunum and ileum of normal subjects after 4 or 8 wk of a high (1,900 mg/d) or a low (200 mg/d) calcium diet. We found that calcium absorption rate was higher when subjects had been on a low than when they had been on a high calcium diet; the ileum responded more rapidly and more completely than the jejunum. Similar results were obtained with magnesium, but only the difference in the ileum was statistically significant. Sodium and xylose absorption were not influenced by dietary calcium intake. The serum concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D were higher on the low than on the high calcium diet. We conclude that the ileum is more sensitive than the jejunum to changes in dietary calcium intake, and that ileal adaptation probably plays a major role in protecting the body against a deficiency or excess of body calcium that otherwise would occur when dietary calcium is abnormally low or high. Calcium intake influences ileal magnesium absorption in a similar fashion; it is not known whether or not this serves a protective function. Our data are compatible with the concept that adaptation to dietary calcium intake is mediated by changes in the serum

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Section: Discussionsupporting

confidence: 89%

Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

Norman¹,

Fordtran²,

Brinkley³

et al. 1981

J. Clin. Invest.

105

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“…In the present study, log[hair Mg] correlated significantly and positively with serum corrected Ca. In patients with chronic renal failure, Mg absorption in the intestine has been reported to be dependent on vitamin D, 39 and to be increased by 1-25-dihydroxyvitamin D. 39 Increased active vitamin D level leads to increases in serum Ca. Serum vitamin D status may be related to the significant, positive correlation between serum corrected Ca and log[hair Mg] observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Hair Magnesium, But Not Serum Magnesium, Is Associated With Left Ventricular Wall Thickness in Hemodialysis Patients

Ochi

Ishimura

Tsujimoto

et al. 2013

Circ J

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“…The active form of vitamin D has been shown to stimulate intestinal Mg absorption [5], which may partly explain depressed Mg absorption reported in CKD patients with a deficiency in active vitamin D [29]. Schmulen et al previously showed that the administration of vitamin D receptor activators enhanced intestinal Mg absorption in CKD patients [30]. Mg-rich foods include green vegetables, peas, beans, nuts, seeds, and some fish [28], which are often restricted to avoid hyperkalemia and hyperphosphatemia.…”

Section: Mg and Dialysis Therapymentioning

confidence: 99%

Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions

Ikee¹

2018

Ren Replace Ther

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Magnesium (Mg) is an essential element that plays pivotal roles in a number of biological processes in the human body. Hypomagnesemia is involved in the pathophysiology of hypertension, vascular calcification, and metabolic derangements including diabetes mellitus and dyslipidemia, which are all risk factors for cardiovascular disease, the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD). Hypomagnesemia is also associated with the development and progression of CKD. As CKD advances, renal Mg excretion decreases and hypermagnesemia emerges in end-stage renal disease (ESRD). In addition, dialysates with high Mg concentrations, which were used in the early era of dialysis therapy, increased the risk of hypermagnesemia, and thus, the dialysate Mg composition has since been reduced. Accordingly, dialysis patients in the modern era commonly have normomagnesemia or even hypomagnesemia. The relationships between hypomagnesemia and cardiovascular disease and mortality have been increasingly reported in observational studies in CKD/ESRD. However, these relationships may be attenuated by a patient's race or region. Although dialysates with higher Mg concentrations or Mg-containing phosphate binders appear to be promising in this setting, only a few interventional studies have examined the effects of Mg supplementation on cardiovascular lesions. Furthermore, the effects of Mg supplementation on mortality have not yet been investigated as a primary end-point in randomized controlled trials. Further studies are required in order to establish the efficacy and safety of Mg in CKD patients.

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Effect of 1,25-(OH)2D3 on jejunal absorption of magnesium in patients with chronic renal disease

Cited by 24 publications

References 0 publications

Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.

Hair Magnesium, But Not Serum Magnesium, Is Associated With Left Ventricular Wall Thickness in Hemodialysis Patients

Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions

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