Effect of 1% Povidone Iodine Mouthwash/Gargle, Nasal and Eye Drop in COVID-19 patient

Abstract

Background: The sudden onset of COVID-19 began in late 2019 caused by a novel coronavirus (SARS-COV2) and on 11th March, WHO declared it to have developed pandemic status. There is still no specific treatment and vaccine available for COVID-19; causing wide spread health problem and concern of the globe. Povidone iodine (PVP-I) is an antiseptic that has been used for over 150 years. It is already proved that different concentration of PVP-I can deactivate COVID-19 virus.
 Methodology: In this randomized controlled clinical trial, out of 1113 patients 606 patients were enrolled and divided in 2 groups by randomization after taken consents. In Gr-A, 303 patients underwent mouthwash/gargle, nasal drops and eye drops with 1% povidone iodine 4 hourly for 4 weeks as well as symptomatic treatment according to need. In Gr-B 303 patients were advised mouthwash/gargle, nasal cavity and eye wash with lukewarm water 4 hourly for 4 weeks and symptomatic treatment according to need. RT-PCR test done every 3rd, 5th and 7th day and Thyroid hormone level (TSH,T3, T4, FT4) at 4th week for follow up.
 Results: The group of patients used 1% PVP-I have shown tremendously reduced mortality, morbidity and hospital as well as financial burden in this covid situation.
 Conclusion: Administration of 1% PVP-I as mouthwash/gargle, nasal or eye drop is simple, rapid and cost effective in reduction of mortality and morbidity by COVID-19.
 Bioresearch Commu. 7(1): 919-923, 2021 (January)

Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

“…[29][30][31][32][33][34][35][36][37][38] Meanwhile, only six studies, reporting the same outcome of interest, were included in the metaanalysis. 30,33,[35][36][37][38] ►Tables 1 and 2 reported the characteristics of the included studies. In this part, the total sample size was 1,339, and the age range was 11 to 90 years.…”

“…In total, we analyzed 10 studies describing the effect of CHX or PVP-I on the SARS-CoV-2 load that were included in the systematic review. [29][30][31][32][33][34][35][36][37][38] Meanwhile, only six studies, reporting the same outcome of interest, were included in the metaanalysis. 30,33,[35][36][37][38] ►Tables 1 and 2 reported the characteristics of the included studies.…”

All-Cause Mortality According to COVID-19 Vaccination Status: an analysis of the UK Office for National Statistics Public Data

“…Finally, but of course not least, besides vaccination many more containment and management strategies exist to fight the COVID-19 pandemic, including primary environmental prevention [43,44], healthy lifestyles [45] such as physical exercise (for example [46][47][48][49][50]), healthy diet (for example [50][51][52]), safe and sustainable therapeutic approaches of documented effectiveness (for example [53][54][55][56][57][58][59]), as well as abandonment of unproven and potentially dangerous treatments [59,60]. Supplementary Materials: Supplementary Tables S1-S8.…”

Usefulness of vaccine boosters for Covid-19 in Italy and in UK and comparison between in intensive care admissions and deaths of vaccinated and unvaccinated patients. Surprises and implications

“…Other strategies as well should be debated and studied in depht and implemented, from allowing natural infections (as Icelandic Public Healthcare is proposing, 27 in the setting of a mild dominant variant such as Omicron), to implementation of safer environments, [28][29][30] healthy lifestyles, [31][32][33][34][35][36] and reasonably effective, safe and sustainable early care. [37][38][39][40][41]…”