2013
DOI: 10.2298/sgs1303147d
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Effect of 10% urea solution on epithelialization of thermally wounded gingiva

Abstract: Introduction. Urea is the final product of protein degradation secreted in saliva. It has low molecular weight and neutral molecule that can freely diffuse through bacterial wall, mature plaque and extracellular polysaccharides exerting a buffering effect. In the presence of urease, urea is broken down into one molecule of ammonia and two molecules of weak carbonic acid, causing alkalization of the substrate and pH increase. Hydrolysis of urea begins at pH 4-6. In mature plaque with low pH, urea hydroly… Show more

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