Effect of 15(r)15 Methylprostaglandin E2 Methyl Ester on Healing of Gastric Ulcers

Fung, Wye-Poh; Karim, S. M. M.; Tye, C. Y.

doi:10.1016/s0140-6736(74)91346-4

Cited by 86 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher doses or analogues of PGF2a may significantly increase the amplitudes of oesophageal peristaltic contractions, making clearance of acid from the gullet more efficient. The profound inhibition of gastric acid secretion by oral methyl derivatives of PGE2 shows that potent pharmacological effects are possible in a related field (Karim, Carter, Bhana, and Ganesan, 1973a, b;Fung, Karim, and Tye, 1974).…”

Section: Discussionmentioning

confidence: 99%

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

Dilawari¹,

Newman²,

Poleo³

et al. 1975

Gut

View full text Add to dashboard Cite

SUMMARY The effects on intraluminal pressure in the oesophagus, the cardiac sphincter, and the gastric fundus of intravenous prostaglandin F2a, E2, and of rectal indomethacin were studied in 41 subjects. Intravenous infusion of prostaglandin F2a (005 to 0-8 ,tg kg-' min-') produced marked, dose-related and sustained elevation of cardiac sphincter pressure without significantly affecting oesophageal peristalsis or gastric fundal motility. Sphincteric relaxation during swallowing was prolonged. Plasma gastrin levels were unchanged. Intravenous infusion of PGE2 (0-08 ,tg kg-' min-') inhibited sphincter contractions to serial bolus intravenous injections of pentagastrin (0.1 or 0-2 ,ug kg-'). Rectal indomethacin (200 mg) resulted in a rise of cardiac sphincter pressure, suggesting that endogenous synthesis of an inhibitory (E-type) prostaglandin was suppressed. The results indicate that prostaglandin E2 may be concerned in the regulation of cardiac sphincter tone in man, whilst prostaglandin F2a may be useful in the treatment of gastrooesophageal reflux.Pressure level in the cardiac sphincter plays a part in the prevention of gastrooesophageal reflux and depends upon the tone of circular oesophageal muscle in that area. The neural and humoral control of sphincteric tone is not completely understood. Human alimentary muscle is highly sensitive to prostaglandins (PGs): in vitro PGE2 produces relaxations and PGF2, contractions of the circular muscle layer (Bennett, Murray, and Wyllie, 1968;Bennett, Eley, and Scholes, 1968;Bennett and Posner, 1971). Prostaglandin E2 occurs naturally in the human gastric mucosa (Bennett, Stamford, and Unger, 1972). We have recorded motor responses of the human gastrooesophageal junction to intravenous PGF2a and PGE2. The effects on cardiac sphincteric pressure of rectally administered indomethacin have also been studied. Methods and SubjectsIntraluminal pressures were measured with a four-'Present address: The Middlesex Hospital, London 2Present address: Mount Sinai Hospital,

show abstract

Section: Discussionmentioning

confidence: 99%

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

Dilawari¹,

Newman²,

Poleo³

et al. 1975

Gut

View full text Add to dashboard Cite

show abstract

“…Wye -Poh Fung et al (1974) found in a similar study a definite healing of gastric ulcer in three out of 10 patients treated for two weeks with 15 R-15-methyl-PGE2 methyl ester and a marked improvement in six other patients. In none of the patients treated in the same conditions but without m-PGE2 was the ulcer niche healed within this period of time.…”

Section: Discussionmentioning

confidence: 76%

“…As this effect of methyl analogues has also been firmly established in humans (Karim et al, 1973a, b;Nylander and Anderson, 1974;Robert et al, 1974;Nylander and Anderson, 1975;Wilson etal., 1975;Konturek etal., 1976), several authors have suggested that m-PGE2 might be effective in the treatment of gastroduodenal ulcer. The first report on the medical applications of m-PGE2 methyl ester suggested that it accelerated ulcer healing (Wye-Poh Fung et al, 1974). However, as, in this study, only 10 cases, all Chinese, and all with gastric ulcer were thus treated, it seemed justifiable for us to study another larger group of patients suffering from duodenal rather than gastric ulcer and this was the aim of the present work.…”

mentioning

confidence: 87%

Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues.

Gibiński¹,

Rybicka²,

Mikoś³

et al. 1977

Gut

View full text Add to dashboard Cite

SUMMARY Seventy-seven patients with gastroduodenal ulcer were treated with two methyl-prostaglandin E2 analogues, m-PGE2, in a double-blind clinical trial. Each of three groups was given 15 S-15 methyl PGE2 methyl ester, 15 R-15 methyl PGE2 methyl ester, and placebo, respectively. Both forms of m-PGE2 analogues appeared to reduce gastric acid secretion, to shorten ulcer healing, and also to produce some side-effects, form 'S' being the more potent. Prompt healing of the ulcer with these agents did not prevent the recurrence of the disease. As the serum gastrin response to a meal after m-PGE2 administration was not reduced, this agent seems directly to affect oxynthic cells.

show abstract

“…When administered to gastric or duodenal ulcer disease patients, it increased the ulcer healing rate compared to patients receiving placebo (Fung et al, 1974;Vantrappen et al, 1982). Arbaprostil has also been shown in experimental animals to protect the stomach against damage induced by the administration of noxious agents, such as HCI, NaOH, absolute ethanol, or boiling water , a property called cytoprotection.…”

Section: Arbaprostil (15(r)-15-methyl Pge2): Lack Of Effect On Theophmentioning

confidence: 99%

Arbaprostil (15(R)‐15‐methyl PGE2): lack of effect on theophylline metabolism.

Reele¹,

Euler²,

McEvers³

et al. 1986

Brit J Clinical Pharma

View full text Add to dashboard Cite

Effect of 15(r)15 Methylprostaglandin E2 Methyl Ester on Healing of Gastric Ulcers

Cited by 86 publications

References 6 publications

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues.

Arbaprostil (15(R)‐15‐methyl PGE2): lack of effect on theophylline metabolism.

Contact Info

Product

Resources

About