Effect of 1α,25(OH)<sub>2</sub>D<sub>3</sub>-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer

Guo, Yi; Jiang, Fei; Yang, Wenqing; Shi, Wenyu; Wan, Jian; Li, Jie; Pan, Jinjing; Wang, Ping; Qiu, Junlan; Zhang, Zengli; Li, Bingyan

doi:10.1080/01635581.2021.2014903

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…The treatment of ovarian cancer cells with 1,25(OH) 2 D 3 decreased the expression of MMP-9 in M2 macrophages [174]. This led to the suppression of cell proliferation and migration abilities in ovarian cancer.…”

Section: Vitamin D In Cancer Treatment and Mmp Regulationmentioning

confidence: 92%

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

Vo,

Nguyen,

Kim

et al. 2023

IJMS

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Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is imperative to the upkeep of various physiological processes including vision, bone health, immunity, and protection against oxidative stress. Current research highlights fat-soluble vitamins as potential therapeutics for human diseases, especially cancer. Fat-soluble vitamins exert their therapeutic effects through multiple pathways, including regulation of matrix metalloproteinases’ (MMPs) expression and enzymatic activity. As MMPs have been reported to be involved in the pathology of various diseases, such as cancers, cardiovascular diseases, and neurological disorders, regulating the expression and/or activity of MMPs could be considered as a potent therapeutic strategy. Here, we summarize the properties of fat-soluble vitamins and their potential as promising candidates capable of effectively modulating MMPs through multiple pathways to treat human diseases.

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Section: Vitamin D In Cancer Treatment and Mmp Regulationmentioning

confidence: 92%

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

Vo,

Nguyen,

Kim

et al. 2023

IJMS

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“…Although it is known that vitamin D affects the immune system and plays an important role in inflammation, little is known about its effect on these hallmarks in OC. One study has shown that 1,25D3 was able to reduce the tumor promoting effect of M2 macrophages in ovarian cancer cells [59]. Another interesting finding was that the vitamin D target human cathelicidin, well known as an effector molecule of the innate immune system, promotes OC progression.…”

Section: Effect Of 125d3 and Its Analogs On Replicative Immortality A...mentioning

confidence: 99%

The Effect of Vitamin D and Its Analogs in Ovarian Cancer

2022

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Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models.

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“…Current evidence suggests that VD-based therapy could potentiate the activity of chemotherapeutic agents and PARPi [216][217][218][219][220][221]. The combination of VD with immunotherapy has also been considered potentially beneficial, given its immunomodulatory effect [222]. However, clinical trials assessing the efficacy of VD-based therapy in OC are lacking.…”

Section: Drug Repurposingmentioning

confidence: 99%

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements

Tavares,

Marques,

Melo

et al. 2024

IJMS

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Ovarian cancer (OC) is the female genital malignancy with the highest lethality. Patients present a poor prognosis mainly due to the late clinical presentation allied with the common acquisition of chemoresistance and a high rate of tumour recurrence. Effective screening, accurate diagnosis, and personalised multidisciplinary treatments are crucial for improving patients’ survival and quality of life. This comprehensive narrative review aims to describe the current knowledge on the aetiology, prevention, diagnosis, and treatment of OC, highlighting the latest significant advancements and future directions. Traditionally, OC treatment involves the combination of cytoreductive surgery and platinum-based chemotherapy. Although more therapeutical approaches have been developed, the lack of established predictive biomarkers to guide disease management has led to only marginal improvements in progression-free survival (PFS) while patients face an increasing level of toxicity. Fortunately, because of a better overall understanding of ovarian tumourigenesis and advancements in the disease’s (epi)genetic and molecular profiling, a paradigm shift has emerged with the identification of new disease biomarkers and the proposal of targeted therapeutic approaches to postpone disease recurrence and decrease side effects, while increasing patients’ survival. Despite this progress, several challenges in disease management, including disease heterogeneity and drug resistance, still need to be overcome.

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Effect of 1α,25(OH)₂D₃-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer

Cited by 8 publications

References 59 publications

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

The Effect of Vitamin D and Its Analogs in Ovarian Cancer

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements

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Effect of 1α,25(OH)2D3-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer

Cited by 8 publications

References 59 publications

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity

The Effect of Vitamin D and Its Analogs in Ovarian Cancer

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements

Contact Info

Product

Resources

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Effect of 1α,25(OH)₂D₃-Treated M1 and M2 Macrophages on Cell Proliferation and Migration Ability in Ovarian Cancer