Effect of 1α-hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated graves' disease

Kawakami-Tani, Takako; Fukawa, Etsushi; Tanaka, Hirotoshi; Abe, Yoshifumi; Makino, Isao

doi:10.1016/s0026-0495(97)90214-6

Cited by 37 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, 1,25(OH) 2 D 3 serum levels were found to be significantly lower in autoimmune hyperthyroidism than in non-autoimmune hyperthyroidism (37), and administration of 1,25(OH) 2 D 3 to patients with untreated Graves' disease was reported to ameliorate hyperthyroidism (38). Blood levels of 1,25(OH) 2 D 3 in patients with type 1 diabetes are significantly reduced, even at disease onset (39).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor genotype is associated with Addison's disease

Pani

Seißler²,

Usadel³

et al. 2002

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Autoimmune Addison's disease is a rare disorder which results from the T cell-mediated destruction of adrenocortical cells. A number of genetic susceptibility markers are shared by Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis. The vitamin D endocrine system has been shown to influence immune regulation. Variants of the nuclear vitamin D receptor (VDR) gene were found to be associated with type 1 diabetes and thyroid autoimmunity amongst others. We therefore investigated the role of VDR polymorphisms in Addison's disease. Design and methods: Patients ðn ¼ 95Þ and controls ðn ¼ 220Þ were genotyped for VDR polymorphisms Fok I, Bsm I, Apa I and Taq I. Results: The 'ff ' (13.7% vs 5.5%; P ¼ 0:0243; odds ratio = 2.75) and the 'tt' (28.4% vs 14.1%; P ¼ 0:0043; odds ratio = 2.42) genotypes were significantly more frequent in patients than in controls. Furthermore, the Bsm I genotype distribution differed significantly between patients and controls ðx 2 ¼ 6:5016 (2 d.f.) P ¼ 0:0387Þ: Conclusions: These data suggest that the VDR genotype is associated with Addison's disease. The mechanisms by which distinct receptor variants might confer disease susceptibility remain to be elucidated.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor genotype is associated with Addison's disease

Pani

Seißler²,

Usadel³

et al. 2002

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Genetic variation in genes involved in vitamin D metabolism has been associated with several autoimmune disorders including autoimmune thyroid disease [2-7]. Several studies suggest that individuals with Graves disease (GD) have lower vitamin D levels than the general population [8-11]; however, data on the relationship between the levels of vitamin D and clinical parameters in GD [12, 13] or therapeutic issues [14-16] are limited. The aim of the present study was to compare vitamin D levels in a large number of newly diagnosed patients with GD with those of the general population and to correlate the vitamin D levels at diagnosis with laboratory and clinical parameters in patients with GD.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics

Planck¹,

Shahida²,

Malm³

et al. 2017

Eur Thyroid J

View full text Add to dashboard Cite

Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase (CYP27B1) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls. Results: Patients with GD had significantly lower vitamin D levels compared to controls (55.0 ± 23.2 vs. 87.2 ± 27.6 nmol/L, p < 0.001). In patients with GD (n = 219), there was no association between the levels of vitamin D at diagnosis and free thyroxine (fT₄), free triiodothyronine (fT₃), thyrotropin receptor antibodies (TRAb), GO at diagnosis, or relapse after terminating treatment with antithyroid drugs. Two SNPs in VDR were associated with GD: rs10735810 (OR = 1.36, 95% CI: 1.02–1.36, p = 0.02) and rs1544410 (OR = 1.47, 95% CI: 1.03–1.47, p = 0.02). There was no difference in the mean vitamin D level between genotypes in either rs10735810 or rs154410. Conclusions: Patients with GD had lower vitamin D levels compared to the general population; however, the vitamin D levels did not affect the laboratory or clinical parameters of GD. SNPs in the VDR influenced the risk of GD through mechanisms other than reducing the vitamin D levels.

show abstract

“…The restoration of euthyroidism was achieved more rapidly in those patients receiving the combined treatment. However, it should be noted that study group was small, the assay employed for detecting TSH-receptor antibodies had a low sensitivity, vitamin D serum levels were not measured, and other factors known to influence the clinical outcome of Graves' hyperthyroidism were not taken into account [15]. Thus, firm conclusion on the beneficial effect of vitamin D in Graves' patients cannot be drawn from this study.…”

mentioning

confidence: 84%

“…Only one such study is available in which patients with Graves' disease were randomized to receive methimazole alone or methimazole ? vitamin D3 (1,25)-OH [15]. The restoration of euthyroidism was achieved more rapidly in those patients receiving the combined treatment.…”

mentioning

confidence: 90%