Effect of 2.45 mT sinusoidal 50 Hz magnetic field on<i>Saccharomyces cerevisiae</i>strains deficient in DNA strand breaks repair

Ruiz-Gómez, Miguel J; Portero, F. Sendra; Martı́nez-Morillo, M.

doi:10.3109/09553001003734519

Cited by 23 publications

(7 citation statements)

References 47 publications

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“…Controversial data have been published concerning the enhancement [31,61], inhibition [62,63] or non-effect of MF exposure with respect to cell proliferation [64,65]. Nevertheless, the scientific contribution of Pasche’s lab seems to be clarifying the potential role of EMFs in proliferation rate control.…”

Section: Biological Effects Of Emfsmentioning

confidence: 99%

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

Artacho‐Cordón¹,

Salinas-Asensio²,

Calvente³

et al. 2013

IJMS

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One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.

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Section: Biological Effects Of Emfsmentioning

confidence: 99%

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

Artacho‐Cordón¹,

Salinas-Asensio²,

Calvente³

et al. 2013

IJMS

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“…Even though a number of studies have reported DNA damage effects from ELF-MFs, the overall results remain inconclusive [9,10,[15][16][17][18][19]. The main reason for this inconsistency was the use of different cell lines.…”

Section: Resultsmentioning

confidence: 99%

“…Reviews of in vivo and in vitro laboratory studies on ELF-MF [1][2][3][4][5][6] have indicated contradictory results from genotoxic endpoints, such as chromosome aberrations, micronuclei, sister chromatid exchange, and DNA strand breakage. These results included increased DNA damage by ELF-MF under specific in vitro and in vivo conditions [7,8], yet no such effects were reported in the other studies [9]. These inconsistent experimental data may be due to the differences in the equipment used to generate magnetic fields, exposure protocols, and biological materials, such as cell lines, animal species, strain, and age.…”

Section: Introductionmentioning

confidence: 99%

Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines

Mun¹,

Lee²,

Kim³

et al. 2015

Journal of electromagnetic engineering and science

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Previously, we investigated extremely low-frequency magnetic fields (ELF-MFs) on diverse DNA damage responses, such as phosphorylated H2AX (γH2AX), comet tail moments, and aneuploidy production in several non-tumorigenic epithelial or fibroblast cell lines. However, the effect of ELF-MF on DNA damage responses in neuronal cells may not be well evaluated. Here, we investigated the effects of ELF-MF on the DNA damage responses in HT22 non-tumorigenic mouse neuronal cells. Exposure to a 60-Hz, 2 mT ELF-MF did not produce any increased γH2AX expression, comet tail moments, or aneuploidy formation. However, 2 mT ELF-MF transiently increased the cell number. From the results, ELF-MF could affect the DNA damage responses differently, depending on the cell lines.Key Words: Aneuploidy, Cell Lines, Comet Tail, Extremely Low Frequency, γH2AX. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ⓒ

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“…It is preferred to induce an error rather than not repair the damage, in order to guarantee the stability of the genome and cell viability [ 7 ]. In S. cerevisiae , the role of HR in DSB repair predominates [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity

González-Vidal,

Mercado-Sáenz,

Burgos-Molina

et al. 2023

Antioxidants

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The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast S. cerevisiae. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied.

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Effect of 2.45 mT sinusoidal 50 Hz magnetic field onSaccharomyces cerevisiaestrains deficient in DNA strand breaks repair

Cited by 23 publications

References 47 publications

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

Effects of 60-Hz Magnetic Fields on DNA Damage Responses in HT22 Mouse Hippocampal Cell Lines

Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity

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