Effect of 2-aminoethoxydiphenyl borate on ischemia-reperfusion injury in a rat ovary model

Taşkın, Mine İslimye; Hişmioğulları, Adnan Adil; Yay, Arzu; Adalı, Ertan; Güngör, Ayşenur; Korkmaz, Gozde Ozge; İnceboz, Ümit

doi:10.1016/j.ejogrb.2014.03.049

Cited by 19 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of several studies showed that 2-APB protects tissues against stress [ 23 – 25 , 49 – 51 ]. In liver, pretreatment with 2-APB was shown to attenuate drug-induced cellular damage and the I/R injury in mice [ 23 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…Reduced I/R injury by 2-APB treatment has been reported in multiple organs with promising results [ 23 – 25 ]. Therefore, we hypothesized that 2-APB may exert a protective effect during cardiac I/R injury through a channel inhibitory effect and assessed the effects of 2-APB administration on ROS-induced cardiomyocyte death or cardiac I/R injury in mice.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

et al. 2017

View full text Add to dashboard Cite

Excessive levels of reactive oxygen species (ROS) and impaired Ca2+ homeostasis play central roles in the development of multiple cardiac pathologies, including cell death during ischemia-reperfusion (I/R) injury. In several organs, treatment with 2-aminoethoxydiphenyl borate (2-APB) was shown to have protective effects, generally believed to be due to Ca2+ channel inhibition. However, the mechanism of 2-APB-induced cardioprotection has not been fully investigated. Herein we investigated the protective effects of 2-APB treatment against cardiac pathogenesis and deciphered the underlying mechanisms. In neonatal rat cardiomyocytes, treatment with 2-APB was shown to prevent hydrogen peroxide (H2O2) -induced cell death by inhibiting the increase in intracellular Ca2+ levels. However, no 2-APB-sensitive channel blocker inhibited H2O2-induced cell death and a direct reaction between 2-APB and H2O2 was detected by 1H-NMR, suggesting that 2-APB chemically scavenges extracellular ROS and provides cytoprotection. In a mouse I/R model, treatment with 2-APB led to a considerable reduction in the infarct size after I/R, which was accompanied by the reduction in ROS levels and neutrophil infiltration, indicating that the anti-oxidative properties of 2-APB plays an important role in the prevention of I/R injury in vivo as well. Taken together, present results indicate that 2-APB treatment induces cardioprotection and prevents ROS-induced cardiomyocyte death, at least partially, by the direct scavenging of extracellular ROS. Therefore, administration of 2-APB may represent a promising therapeutic strategy for the treatment of ROS-related cardiac pathology including I/R injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In groups 3, 4, and 5, after the same torsion procedure, detorsion was performed and the incision line was closed using 3/0 silk suture. All surgical procedures were performed by the same researchers, and all rats were killed after completing the surgical operations …”

Section: Methodsmentioning

confidence: 99%

“…All surgical procedures were performed by the same researchers, and all rats were killed after completing the surgical operations. [20][21][22]…”

Section: Surgical Methodsmentioning

confidence: 99%

What is the protective effect of metformin on rat ovary against ischemia‐reperfusion injury?

Sayan

Karaca

Özkan

et al. 2017

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…Assuming that detorsion can provoke this injury and alone is insufficient to protect ovarian reserve as the follicle count decreases (Ozler et al [38]), several agents, including antiinflammatories and antioxidant drugs, have been evaluated to determine whether they have a protective effect [36]. Experimental studies were performed on rat ovaries to demonstrate the role of different drugs in the protection of ovarian function [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. Gradual detorsion can also reduce reperfusion injury in a rat model of ovarian torsion [37].…”

Section: Effects Of Reperfusion After Detorsion: Experimental Studiesmentioning

confidence: 99%

Adnexal torsion in adolescents

Spinelli

Piscioneri

Strambi

2015

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

A systematic review of physiopathology, clinical picture, and imaging of adnexal torsion is certainly useful to identify as soon as possible this emergency condition. An early identification and an adequate treatment are indispensable in order to achieve a proper outcome for the patient. The choice of the appropriate surgical approach can be challenging and should be made on the basis of an accurate evaluation of the ovarian lesion. Therefore, it would be useful to perform an intraoperative frozen section analysis in selected cases.

show abstract

Effect of 2-aminoethoxydiphenyl borate on ischemia-reperfusion injury in a rat ovary model

Cited by 19 publications

References 33 publications

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

What is the protective effect of metformin on rat ovary against ischemia‐reperfusion injury?

Adnexal torsion in adolescents

Contact Info

Product

Resources

About