Effect of 2-Thioxo Imidazolidin-4-Ones derivative copper complex on the oxidative state on the male rats exposed to hydrogen peroxide

Abstract

In this work, a new thioxoimidazolidine derivative had been prepared by the reaction of bromobenzaldehyde with thiosemicarbazide then the resulting product reacted with ethelchloroacetate to produce the ligand, L= (3{(E)[(4-bromophenyl) methyldenamino-2-sulfanylideneimidazo lidin-4-one, in an attempt to synthesis its copper complex. The new ligand and its copper complex was isolated, studied and characterized in solid states by studying the analytical and physicochemical properties. It was found that ligand coordinate to copper ion as a bidentate ligand through nitrogen atom of Azomethine groups and sulfur atoms of the thione group. The outcomes recorded that copper complex could be founds in "[1:2] (M:L) molar ratio". From study of geometrical shape, the copper ion has a square planer shape with Ligand. Twenty-four adult male rats were divided into three equal groups, with age 2-3 months old. The first group returned to the control group, as it was given the necessary food and water, second, third group was given 0.5% hydrogen peroxide in drinking water. The third group was dosage by orally copper complex of 2-Thioxo Imidazolidin-4-Ones by Cavage Needle. after thirty and sixty days of experimental period, blood sample was drawn from each animal.