2024
DOI: 10.3892/etm.2024.12527
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Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action

Boyu Tan,
Xiaoxu Lan,
Yifan Zhang
et al.

Abstract: The present study aimed to investigate the effect and mechanism of Pulsatilla compounds on lung adenocarcinoma. The representative drug chosen was the compound 23-HBA. GeneCards, Swiss target prediction, DisGeNET and TCMSP were used to screen out related genes, and MTT and flow cytometry assays were used to verify the inhibitory effect of Pulsatilla compounds on the proliferation of lung adenocarcinoma cells. Subsequently, the optimal target, peroxisome proliferator-activated receptor (PPAR)-γ, was selected us… Show more

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