Effect of 25-hydroxyvitamin D<sub>3</sub> and 1,25-dihydroxyvitamin
D<sub>3</sub> maternal loads on maternal and fetal vitamin D metabolite levels
in the rat

Rebut-Bonneton, C; Cancela, Leonor; Miravet, L

doi:10.1051/rnd:19850410

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Concentrations of 25-hydroxy¬ vitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (l,25-(OH)2D3) were determined in individual 1-2 ml serum samples. Extraction was performed using a previously described method (Rebut-Bonneton, Demignon, Cancela & Miravet 1985). Fractions con¬ taining either 25-OH-D or l,25-(OH)2D3 were separ¬ ated using Sep-Pak silica cartridges (Waters, Monigny Le Bretonneux, France) (Adams, Clemens & Hollick, 1981) and further purified by high pressure liquid chromatography (HPLC), developed with hexane : isopropanol, 95: 5 (v/v), for 25-OH-D and 90: 10 (v/v) for l,25-(OH)2D3, before quantitation.…”

Section: Serum Determinationsmentioning

confidence: 99%

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Cancela¹,

Boulch²,

Miravet³

1986

Journal of Endocrinology

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This work was designed to study the effect of the vitamin D content of human milk on the vitamin D status of exclusively breast-fed infants, and the relation between milk and maternal serum concentrations of vitamin D during the first month of lactation. Serum levels of calcium (Ca), phosphorus (P), magnesium (Mg) and 25-hydroxyvitamin D (25-OH-D) were determined in a racially heterogeneous population of nursing women, between days 3 and 5 (L3), 15 and 18 (L15) and 30 and 45 (L30) post partum. The same parameters were determined in the serum of 1-month-old breast-fed infants. Maternal milk samples were obtained at L3, L15 and L30 and analysed for Ca, P, Mg, vitamin D and 25-OH-D content. Milk levels of Ca, P and Mg were found to be within the range previously described by other authors. No correlation was found between serum and milk levels of vitamin D and 25-OH-D in nursing mothers. The 25-OH-D concentration in milk was related to its vitamin D content and strongly correlated (P less than 0.001) with the 25-OH-D levels in the serum of exclusively breast-fed infants. No significant changes were observed in maternal serum levels of 1,25-dihydroxyvitamin D (1,25-(OH)2D3) measured at L3 and L30, or between maternal and infant levels of 1,25-(OH)2D3 at L30. This study emphasizes the importance of the 25-OH-D content of maternal milk, in being primarily responsible for the vitamin D concentrations found in the serum of exclusively breast-fed infants.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Serum Determinationsmentioning

confidence: 99%

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Cancela¹,

Boulch²,

Miravet³

1986

Journal of Endocrinology

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“…16 In rats, 25(OH)D readily crosses into the fetal circulation, but 1,25(OH)2D does not seem to cross to a significant degree. 17 As well, 1-a-hydroxylation of 25(OH)D to 1,25(OH)2D in the fetal kidneys is regulated independently of maternal vitamin D status, and is relatively suppressed in the fetus. 18 Fetal [1,25(OH)2D] likely remains low because the transplacental unidirectional calcium flow that maintains physiological fetal 'hypercalcemia' relative to the maternal circulation is primarily regulated by PTH-related protein, 19 and perhaps PTH.…”

Section: -Hydroxyvitamin D ([25(oh)d]mentioning

confidence: 99%

Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials

Roth

2011

J Perinatol

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Maternal-child health benefits of optimizing vitamin D status during pregnancy may include a reduced risk of pre-eclampsia, improved fetal growth and beneficial effects on infant immune function. These hypotheses require evaluation by randomized controlled antenatal vitamin D supplementation trials using doses that are high enough to elevate serum 25-hydroxyvitamin D concentrations into the range believed to be associated with improved health outcomes. Such doses may be considerably higher than the current recommended dietary allowance (600 IU day -1 ) or standard prenatal supplement dose (400 IU day -1 ), and may even be higher than the tolerable upper intake level (4000 IU day -1 ) advised by the Institute of Medicine (2010). A critical review of the published literature yielded limited data regarding the safety of antenatal vitamin D regimens. There have been no published reports of the teratogenic effects of vitamin D on humans. Some animal studies have suggested the potential for dosedependent fetal toxicities (for example, growth impairment, skeletal malformations and cardiovascular anomalies), but the relevance of these observations to humans is unknown. Antenatal vitamin D supplementation trials should incorporate a range of methods for objectively establishing maternal and fetal safety, and aim to identify the lowest doses of vitamin D required to achieve target outcomes.

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Neonatal Vitamin Metabolism: Fat Soluble

Greer¹,

Zachman²

1998

Principles of Perinatal—Neonatal Metabolism

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Effect of 25-hydroxyvitamin D₃ and 1,25-dihydroxyvitamin D₃ maternal loads on maternal and fetal vitamin D metabolite levels in the rat

Abstract: Introduction.

Cited by 6 publications

References 13 publications

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials

Neonatal Vitamin Metabolism: Fat Soluble

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Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat

Abstract: Introduction.

Cited by 6 publications

References 13 publications

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials

Neonatal Vitamin Metabolism: Fat Soluble

Contact Info

Product

Resources

About

Effect of 25-hydroxyvitamin D₃ and 1,25-dihydroxyvitamin D₃ maternal loads on maternal and fetal vitamin D metabolite levels in the rat