Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial

Durga, Jane; Boxtel, M.P.J. van; Schouten, Evert G.; Kok, F.J.; Jolles, Jelle; Katan, Martijn B.; Verhoef, Petra

doi:10.1016/s0140-6736(07)60109-3

Cited by 651 publications

(512 citation statements)

References 38 publications

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“…In a 3-year study of the elderly, a daily intake of 800 mg of oral folic acid significantly improved those domains of cognitive function that deteriorate with age. 23 …”

Section: Psychiatric Disordersmentioning

confidence: 99%

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

2009

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“…In a 3-year study of the elderly, a daily intake of 800 mg of oral folic acid significantly improved those domains of cognitive function that deteriorate with age. 23 …”

Section: Psychiatric Disordersmentioning

confidence: 99%

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

2009

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“…Folic acid consumption, with or without vitamin B 12 , may help prevent cognitive impairment in the elderly, possibly through lowering plasma homocysteine levels (12,13) . A 3-year randomised double-blind placebocontrolled trial involving >800 older adults (aged 50-70 years, all vitamin B 12 replete) in The Netherlands has found that supplements of 800 mg folic acid over 3 years improve cognitive function (14) . Improvements in this trial were found to involve domains of cognitive function associated with ageing and these changes were shown to be associated with reductions in homocysteine (14) .…”

Section: Cognitive Functionmentioning

confidence: 99%

Session 1: Public health nutrition Folic acid food fortification: the Irish experience

et al. 2008

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Adequate intake of folic acid by women during very early pregnancy can markedly reduce risk of the development of neural-tube defects (NTD). The effectiveness of advice to women to take folic acid supplements is limited, mainly because 50 % of pregnancies are unplanned. However, mandatory folic acid food fortification programmes in North America have been very successful in reducing NTD rates. In Ireland higher rates of pregnancies are affected by NTD and the option of termination is illegal. Consequently, the much higher burden of disease makes primary prevention of NTD an important public health issue in Ireland. During 2006 a decision was taken in Ireland to initiate mandatory folic acid fortification of most bread to prevent NTD. Priority work was immediately undertaken to establish reliable and comprehensive baseline information on factors that will be affected by fortification. This information included data on: the national prevalence of pregnancies affected by NTD; the current extent of voluntary folic acid fortification of food on the Irish market and how it affects folic acid intakes; blood folate status indicators assessed for various subgroups of the Irish population. In addition, scientific developments that have arisen since 2006 relating to the risks and benefits of folic acid intake are under ongoing review. The present paper summarises the rationale for mandatory folic acid food fortification in Ireland and recent scientific developments relating to risks and benefits of folic acid intake. In this context, preliminary findings of baseline monitoring investigations in Ireland are considered.

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“…One of the relevant environmental factors seems to be food. There is a growing awareness that food may play a role in determining not only our physical well-being, but also our behaviour and cognitive functioning [6][7][8]. The role of food in ADHD has been investigated since 1985 in several restricted elimination diet (RED) studies.…”

mentioning

confidence: 99%

Is there a future for restricted elimination diets in ADHD clinical practice?

Rommelse¹,

Buitelaar²

2013

Eur Child Adolesc Psychiatry

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Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial

Abstract: Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age.

Cited by 651 publications

References 38 publications

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review

Session 1: Public health nutrition Folic acid food fortification: the Irish experience

Is there a future for restricted elimination diets in ADHD clinical practice?

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