Effect of 4-nonylphenol on the immune response of the Pacific oyster Crassostrea gigas following bacterial infection with Vibrio campbellii

Hart, Courtney E.; Lauth, Michael; Hunter, Cassidy S.; Krasny, Brennan R.; Hardy, Kristin M.

doi:10.1016/j.fsi.2016.09.054

Cited by 25 publications

(11 citation statements)

References 99 publications

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“…At the same stage, all the sediments significantly decrease its expression to similar levels. In a previous study using naïve oysters exposed to low levels of NP, despite the decrease of lysozyme-1 mRNA levels, an increase of its associated activity was measured (Hart et al, 2016). This was caused by the release of existing lysozyme stores and possibly suggests that similarly in our study, organisms fight using the stored protein thus preventing new mRNA requirements and subsequent enzyme synthesis.…”

Section: Discussionsupporting

confidence: 41%

“…ROS content in the organism can be increased by the presence of contaminants and is regulated by antioxidant enzymes, such as superoxide dismutase (Sod) and glutathione peroxidase (GPx) (Cheung et al, 2004;Verlecar et al, 2007). Other immune parameters such as lysozyme activity, may also be modulated by contaminants (Hart et al, 2016) The main goal of the present study was to investigate the toxicity of three different "C" class sediments following a Weight of evidence approach, integrating data regarding the chemical characterization, with biological results obtained exposing sentinel species to contaminated sediments, according to the recent Italian legislation for a better management of dredged marine sediments.…”

Section: Introductionmentioning

confidence: 99%

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Dietary diisononylphthalate contamination induces hepatic stress: a multidisciplinary investigation in gilthead seabream (Sparus aurata) liver

et al. 2019

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IndexGeneral Introduction…………………………………………………………………………….p. 4 1. The coast: a delicate environment 2. The specific problems of the coastal environment: between society and environment 3. Characteristics of marine sediment 4. Source of pollution of marine sediment 5. Dredging activity 6. Chemistry versus Ecotoxicology 7. The regulatory framework (laws) 8. Molecular investigation Aims and organization of the thesis……………………………………………………………p. 21 Chapter 1. Chemical and ecotoxicological analysis of 21 sediments from harbour dredging activity…………………………………………………………………………………………...p. 23 Inorganic fractionCharacterized by clay and non-silicates, carbonates, iron and manganese oxides, phosphates and sulphides. Organic fractionConsisting of living organisms, xenobiotic compounds and natural organic substance, which is very variable and can consist of proteins, peptides, humic and fulvic material. Interstitial WaterWhich can be up to about 50% by volume. PollutantInorganic or organic. 23Chapter 1 Chemical and ecotoxicological analysis of 21 sediments from harbour dredging activity

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Section: Discussionsupporting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Dietary diisononylphthalate contamination induces hepatic stress: a multidisciplinary investigation in gilthead seabream (Sparus aurata) liver

et al. 2019

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“…BPA could also exert negative impacts on the regulation of immune-associated genes in medaka (95) and juvenile common carp ( Cyprinus carpio ) (93). NP regulates various elements of the innate immune response in the Pacific oyster that was induced by bacterial infection (96). Exposure to 17alpha-ethylinestadiol (EE2) affected a large number of pathways associated with immune system in fathead minnow (97).…”

Section: Discussionmentioning

confidence: 99%

Differential Hepatic Gene Expression Profile of Male Fathead Minnows Exposed to Daily Varying Dose of Environmental Contaminants Individually and in Mixture

et al. 2018

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Environmental contaminants are known to impair reproduction, metabolism and development in wild life and humans. To investigate the mechanisms underlying adverse effects of contaminants, fathead minnows were exposed to a number of endocrine disruptive chemicals (EDCs) including Nonylphenol (NP), bisphenol-A (BPA), Di(2-ethylhexyl) phthalate (DEHP), and a mixture of the three chemicals for 21 days, followed by determination of the liver transcriptome by expression microarrays. Pathway analysis revealed a distinct mode of action for the individual chemicals and their mixture. The results showed expression changes in over 980 genes in response to exposure to these EDC contaminants individually and in mixture. Ingenuity Pathway core and toxicity analysis were used to identify the biological processes, pathways and the top regulators affected by these compounds. A number of canonical pathways were significantly altered, including cell cycle & proliferation, lipid metabolism, inflammatory, innate immune response, stress response, and drug metabolism. We identified 18 genes that were expressed in all individual and mixed treatments. Relevant candidate genes identified from expression microarray data were verified using quantitative PCR. We were also able to identify specific genes affected by NP, BPA, and DEHP individually, but were also affected by exposure to the mixture of the contaminants. Overall the results of this study provide novel information on the adverse health impact of contaminants tested based on pathway analysis of transcriptome data. Furthermore, the results identify a number of new biomarkers that can potentially be used for screening environmental contaminants.

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“…It is downregulated in pearl sacs that yield pearls with underskin defects. Hemocyte protein-glutamine gamma-glutamyltransferase (transglutaminases) have been implicated in the immune response of the Pacific oyster C. gigas (Gueguen et al, 2003;Hart et al, 2016), suggesting that the underskin defect may be related to infection within the pearl sac. One of the unannotated transcripts (c66069_g1_i1) was likely also identified as being associated with pearl quality in the study by Le Luyer et al (2019).…”

Section: Underskinmentioning

confidence: 99%

Pearl Sac Gene Expression Profiles Associated With Pearl Attributes in the Silver-Lip Pearl Oyster, Pinctada maxima

et al. 2021

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Pearls are highly prized biomineralized gemstones produced by molluscs. The appearance and mineralogy of cultured pearls can vary markedly, greatly affecting their commercial value. To begin to understand the role of pearl sacs—organs that form in host oysters from explanted mantle tissues that surround and synthesize pearls—we undertook transcriptomic analyses to identify genes that are differentially expressed in sacs producing pearls with different surface and structural characteristics. Our results indicate that gene expression profiles correlate with different pearl defects, suggesting that gene regulation in the pearl sac contributes to pearl appearance and quality. For instance, pearl sacs that produced pearls with surface non-lustrous calcification significantly down-regulate genes associated with cilia and microtubule function compared to pearl sacs giving rise to lustrous pearls. These results suggest that gene expression profiling can advance our understanding of processes that control biomineralization, which may be of direct value to the pearl industry, particularly in relation to defects that result in low value pearls.

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Effect of 4-nonylphenol on the immune response of the Pacific oyster Crassostrea gigas following bacterial infection with Vibrio campbellii

Cited by 25 publications

References 99 publications

Dietary diisononylphthalate contamination induces hepatic stress: a multidisciplinary investigation in gilthead seabream (Sparus aurata) liver

Dietary diisononylphthalate contamination induces hepatic stress: a multidisciplinary investigation in gilthead seabream (Sparus aurata) liver

Differential Hepatic Gene Expression Profile of Male Fathead Minnows Exposed to Daily Varying Dose of Environmental Contaminants Individually and in Mixture

Pearl Sac Gene Expression Profiles Associated With Pearl Attributes in the Silver-Lip Pearl Oyster, Pinctada maxima

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