Effect of (4a) a novel 5-HT₃ receptor antagonist on chronic unpredictable mild stress induced depressive-like behavior in mice: an approach using behavioral tests battery

Abstract

(4a) exhibits antidepressant potential by reversing the CUMS induced behavioral and biochemical changes in mice.

The Potential of Moringa oleifera to Induce Cerebral Leptin mRNA Expression and to Attenuate Oxidative Stress, Cognitive and Motor Deficits, Depression- and Anxiety- Like Behavior in Experimental Obese Model

“…Brain dysfunction is considered a potential results of obesity as a stressful condition implicated in induction of ROS and oxidative stress 56 . Various studies were in agreement with the present work, and reported the direct correlation between depression and raising of brain MDA, and reduction in brain GSH in mice 39,53 . Oxidative stress shows deleterious effects that would lead to neuronal cell death, which is accompanied by memory impairment in the rats 54,55 .…”

Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress

“…However, current research provides limited evidence regarding the effect of escitalopram on oxidative stress markers in different brain areas of stress-depressed rats. Escitalopram was demonstrated to regulate CUMS induced oxidative stress by suppressing lipid peroxidation (i.e., MDA or TBARS) or increasing the levels of antioxidant molecules (i.e., GSH, GPx, catalase, SOD) in the whole brain or prefrontal cortex [31,49,54,64,65,67]. Conversely, Eren et al (2007) and Martin-Hernandez et al (2018) reported decreased lipid peroxidation (quantified by MDA or TBARS) in the prefrontal cortex of CUMS subjected rats, while Wigner et al (2020) showed that catalase mRNA expression in the hippocampus and cerebral cortex was reduced after escitalopram administration in comparison with stressed animals [19,31,64].…”

“…Escitalopram is an established antidepressant recommended as first line treatment of depression by current international guidelines [ 44 ]. Also, several studies proved escitalopram’s antidepressant effect on rat behaviour induced by chronic unpredictable stress, including improvement of the sensitivity to reward (i.e., sucrose preference) or anxiety measured by EPM [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. In line with previous research, our results demonstrated that escitalopram, either in 5 mg/day b.w.…”

Ondansetron attenuates co-morbid depression and anxiety associated with obesity by inhibiting the biochemical alterations and improving serotonergic neurotransmission

“…Ondansetron, a 5-HT 3 receptor antagonist is currently being used for the treatment of post-operative nausea and vomiting (PONV) and chemotherapy induced nausea and vomiting (CINV) (Tramer et al, 1997;Parker et al, 2001;Cohen, 2007). Several preclinical studies have demonstrated the antidepressant and anxiolytic effects of serotonergic type 3 (5-HT 3 ) receptor antagonists, such as ondansetron (Ramamoorthy et al, 2008;Rajkumar and Mahesh, 2010;Roychoudhury and Kulkarni, 1997), 3-methoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) (Kurhe et al, 2014a) and (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a) (Kurhe et al, 2015). Earlier we reported the antidepressant activity of ondansetron based on the behavioral tests in obese mice subjected to chronic stress (Kurhe et al, 2014b).…”